Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2785313..2785575 Replicon chromosome
Accession NZ_CP015645
Organism Staphylococcus aureus strain 08-02119

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A7P66_RS14100 Protein ID WP_001802298.1
Coordinates 2785313..2785417 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2785412..2785575 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P66_RS14090 2782109..2782891 + 783 WP_000908174.1 ABC transporter ATP-binding protein -
A7P66_RS14095 2782959..2783816 + 858 WP_000370931.1 Cof-type HAD-IIB family hydrolase -
A7P66_RS14800 2784475..2784633 - 159 WP_001792784.1 hypothetical protein -
A7P66_RS14100 2785313..2785417 + 105 WP_001802298.1 hypothetical protein Toxin
- 2785412..2785575 - 164 - - Antitoxin
A7P66_RS14105 2786225..2787871 + 1647 WP_000277718.1 IS1182 family transposase -
A7P66_RS14110 2787900..2788991 - 1092 WP_000495672.1 hypothetical protein -
A7P66_RS14115 2789257..2790237 - 981 WP_000019739.1 CDF family zinc efflux transporter CzrB -
A7P66_RS14120 2790239..2790559 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2786225..2787871 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T63300 WP_001802298.1 NZ_CP015645:2785313-2785417 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T63300 NZ_CP015645:2785313-2785417 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT63300 NZ_CP015645:c2785575-2785412 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References