Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2532233..2532750 Replicon chromosome
Accession NZ_CP015645
Organism Staphylococcus aureus strain 08-02119

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag A7P66_RS12760 Protein ID WP_000113262.1
Coordinates 2532484..2532750 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag A7P66_RS12755 Protein ID WP_000584499.1
Coordinates 2532233..2532484 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P66_RS12725 2527931..2528650 + 720 WP_000479576.1 amino acid ABC transporter permease -
A7P66_RS12730 2528647..2529378 + 732 WP_042909118.1 amino acid ABC transporter ATP-binding protein -
A7P66_RS12735 2529475..2530725 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
A7P66_RS12740 2530980..2531342 + 363 WP_000819843.1 DUF4467 domain-containing protein -
A7P66_RS12745 2531361..2531960 + 600 WP_000162810.1 DsbA family protein -
A7P66_RS12750 2531967..2532068 + 102 Protein_2424 hypothetical protein -
A7P66_RS12755 2532233..2532484 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7P66_RS12760 2532484..2532750 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
A7P66_RS12765 2533044..2534594 + 1551 WP_042909117.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
A7P66_RS12770 2534780..2535247 + 468 WP_000153344.1 SRPBCC domain-containing protein -
A7P66_RS12775 2535334..2535516 + 183 WP_000079142.1 hypothetical protein -
A7P66_RS12780 2535733..2536557 + 825 WP_000572040.1 formate/nitrite transporter family protein -
A7P66_RS12785 2536791..2537327 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T63299 WP_000113262.1 NZ_CP015645:2532484-2532750 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T63299 NZ_CP015645:2532484-2532750 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT63299 WP_000584499.1 NZ_CP015645:2532233-2532484 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT63299 NZ_CP015645:2532233-2532484 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References