Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2507257..2507441 Replicon chromosome
Accession NZ_CP015645
Organism Staphylococcus aureus strain 08-02119

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag A7P66_RS12605 Protein ID WP_000482647.1
Coordinates 2507257..2507364 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2507381..2507441 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P66_RS12580 2502629..2503102 + 474 WP_000456492.1 GyrI-like domain-containing protein -
A7P66_RS12585 2503225..2504436 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
A7P66_RS12590 2504618..2505277 - 660 WP_000831295.1 hypothetical protein -
A7P66_RS12595 2505337..2506479 - 1143 WP_001176863.1 glycerate kinase -
A7P66_RS12600 2506737..2507123 + 387 WP_000779360.1 flippase GtxA -
A7P66_RS12605 2507257..2507364 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2507381..2507441 - 61 - - Antitoxin
A7P66_RS12615 2508068..2509831 + 1764 WP_001064836.1 ABC transporter ATP-binding protein/permease -
A7P66_RS12620 2509856..2511589 + 1734 WP_000486496.1 ABC transporter ATP-binding protein/permease -
A7P66_RS12630 2511820..2511987 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T63297 WP_000482647.1 NZ_CP015645:2507257-2507364 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T63297 NZ_CP015645:2507257-2507364 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT63297 NZ_CP015645:c2507441-2507381 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References