Detailed information of TA system TA063292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 605440..606019
• Replicon: chromosome
• Accession: NZ_CP015645
• Organism: Staphylococcus aureus strain 08-02119

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: A7P66_RS03275
• Protein ID: WP_001025401.1
• Coordinates: 605440..605685 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	605654..606019 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7P66_RS14840	601327..601948	+	622	Protein_584	ATPase	-
A7P66_RS03240	601945..602091	-	147	WP_001013104.1	hypothetical protein	-
A7P66_RS03245	602127..602309	-	183	WP_000705240.1	hypothetical protein	-
A7P66_RS03250	602405..603325	-	921	WP_000348133.1	3'-5' exoribonuclease	-
A7P66_RS03255	603341..603955	-	615	WP_000801423.1	XRE family transcriptional regulator	-
A7P66_RS03260	604127..604354	+	228	WP_001030311.1	hypothetical protein	-
A7P66_RS03265	604380..605156	+	777	WP_001148559.1	phage antirepressor	-
A7P66_RS03270	605172..605390	+	219	WP_001001383.1	hypothetical protein	-
A7P66_RS03275	605440..605685	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
A7P66_RS03280	605654..606019	-	366	WP_001128433.1	hypothetical protein	Antitoxin
A7P66_RS03285	606074..606289	+	216	WP_001097552.1	hypothetical protein	-
A7P66_RS03290	606314..606577	+	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
A7P66_RS03295	606589..606750	+	162	WP_015986189.1	DUF1270 family protein	-
A7P66_RS03300	606829..607152	+	324	WP_000174995.1	hypothetical protein	-
A7P66_RS03305	607167..607529	+	363	WP_049286545.1	hypothetical protein	-
A7P66_RS03310	607526..608692	+	1167	WP_049286546.1	DUF2800 domain-containing protein	-
A7P66_RS03315	608718..609275	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	597007..645672	48665

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T63292 WP_001025401.1 NZ_CP015645:605440-605685 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T63292 NZ_CP015645:605440-605685 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCTGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT63292 NZ_CP015645:c606019-605654 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin