Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 32332..32855 Replicon plasmid unnamed1
Accession NZ_CP015643
Organism Staphylococcus simulans strain MR1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag A7X73_RS12990 Protein ID WP_106421233.1
Coordinates 32589..32855 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag A7X73_RS12985 Protein ID WP_106421232.1
Coordinates 32332..32589 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7X73_RS12955 27919..28524 + 606 WP_106421227.1 sporulation delaying protein family toxin -
A7X73_RS12960 28527..28913 + 387 WP_106421228.1 DUF393 domain-containing protein -
A7X73_RS12965 28954..29595 - 642 WP_106421229.1 SdpI family protein -
A7X73_RS12970 29614..29865 - 252 WP_106421230.1 autorepressor SdpR family transcription factor -
A7X73_RS12975 30933..31415 + 483 Protein_41 recombinase family protein -
A7X73_RS12985 32332..32589 + 258 WP_106421232.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7X73_RS12990 32589..32855 + 267 WP_106421233.1 Txe/YoeB family addiction module toxin Toxin
A7X73_RS12995 33462..34136 + 675 WP_103370613.1 IS6 family transposase -
A7X73_RS13000 34146..34991 - 846 WP_106421234.1 protein rep -
A7X73_RS13005 35530..36075 - 546 WP_105988897.1 hypothetical protein -
A7X73_RS13015 37172..37315 - 144 WP_106421236.1 Rep protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid lnu(A) - 1..87667 87667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.14 Da        Isoelectric Point: 10.0751

>T63288 WP_106421233.1 NZ_CP015643:32589-32855 [Staphylococcus simulans]
MSNYSISIKNSAKSDLKKIQQSQLKSHFLKIVEILKIDPYYPNQSFEKLQPKHLGRYSRRINHQHRVVYTVDEERKEVYI
FSAWSHYE

Download         Length: 267 bp

>T63288 NZ_CP015643:32589-32855 [Staphylococcus simulans]
ATGAGTAACTACAGTATTTCAATTAAAAATTCGGCGAAAAGTGATTTAAAAAAAATACAGCAGTCACAACTTAAAAGTCA
TTTTTTAAAAATTGTAGAAATATTAAAGATAGACCCATATTATCCAAACCAATCATTTGAAAAGTTACAACCAAAACATT
TAGGGCGCTATTCAAGGCGTATCAATCATCAGCATAGAGTAGTTTATACAGTCGATGAAGAAAGAAAAGAAGTATATATT
TTTTCTGCGTGGTCTCATTATGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9832.82 Da        Isoelectric Point: 4.3646

>AT63288 WP_106421232.1 NZ_CP015643:32332-32589 [Staphylococcus simulans]
MNIKTPTNARKEFYELLKQVNNNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVREREKDDSGYTNIDDL
DWDNL

Download         Length: 258 bp

>AT63288 NZ_CP015643:32332-32589 [Staphylococcus simulans]
ATGAATATTAAAACTCCTACAAATGCGAGAAAAGAGTTTTACGAGCTGTTAAAACAAGTTAATAATAATCATGAGCCTGT
AATTATAAGTGGCTCTAAAAGTGAAAATAACGCAGTTATTGTAAGTCAAAAAGATTGGAATAGTATTCAAGAAACGTTGT
TTCTTGAATCAACTGGCACTATGGATAAAGTAAGAGAACGTGAAAAAGATGATAGTGGTTATACAAATATTGATGATTTA
GATTGGGATAACTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References