63274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 94190..94713 Replicon chromosome
Accession NZ_CP015626
Organism Staphylococcus pseudintermedius strain 063228

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T7NYR3
Locus tag A6M57_RS00415 Protein ID WP_065520308.1
Coordinates 94447..94713 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3D8YKM0
Locus tag A6M57_RS00410 Protein ID WP_014612814.1
Coordinates 94190..94447 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6M57_RS00390 89530..89712 - 183 WP_041613203.1 hypothetical protein -
A6M57_RS00395 (A6M57_0420) 90238..91044 + 807 WP_014612811.1 arylamine N-acetyltransferase -
A6M57_RS00400 (A6M57_0425) 91338..91832 - 495 WP_015729749.1 isoprenylcysteine carboxylmethyltransferase family protein -
A6M57_RS00405 (A6M57_0430) 92092..93996 + 1905 WP_020219985.1 triacylglycerol lipase -
A6M57_RS00410 (A6M57_0435) 94190..94447 + 258 WP_014612814.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6M57_RS00415 (A6M57_0440) 94447..94713 + 267 WP_065520308.1 Txe/YoeB family addiction module toxin Toxin
A6M57_RS00420 95064..95165 - 102 WP_019169745.1 SE2200 family small protein -
A6M57_RS00425 (A6M57_0450) 95179..96672 - 1494 WP_014612817.1 L-lactate dehydrogenase (quinone) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10532.09 Da        Isoelectric Point: 10.1217

>T63274 WP_065520308.1 NZ_CP015626:94447-94713 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEMLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Download         Length: 267 bp

>T63274 NZ_CP015626:94447-94713 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGATGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9866.87 Da        Isoelectric Point: 4.1100

>AT63274 WP_014612814.1 NZ_CP015626:94190-94447 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT63274 NZ_CP015626:94190-94447 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7NYR3

Antitoxin

Source ID Structure
AlphaFold DB A0A3D8YKM0

References