63264

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4297841..4298493 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name higB Uniprot ID A0A1B1KVK6
Locus tag Q5A_RS19930 Protein ID WP_006318939.1
Coordinates 4297841..4298185 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Q5A_RS19935 Protein ID WP_006318938.1
Coordinates 4298191..4298493 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS19915 4295069..4296088 + 1020 WP_006318942.1 HTH-type transcriptional regulator GalR -
Q5A_RS19920 4296085..4296540 - 456 WP_006318941.1 GNAT family N-acetyltransferase -
Q5A_RS19925 4296692..4297702 + 1011 WP_006318940.1 LacI family DNA-binding transcriptional regulator -
Q5A_RS19930 4297841..4298185 + 345 WP_006318939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q5A_RS19935 4298191..4298493 + 303 WP_006318938.1 helix-turn-helix transcriptional regulator Antitoxin
Q5A_RS19940 4298523..4299785 - 1263 WP_006318937.1 diaminopimelate decarboxylase -
Q5A_RS19945 4299920..4300843 + 924 WP_006318927.1 LysR family transcriptional regulator -
Q5A_RS19950 4300833..4301987 - 1155 WP_006318926.1 MFS transporter -
Q5A_RS19955 4302305..4303213 - 909 WP_006318925.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13346.40 Da        Isoelectric Point: 10.1513

>T63264 WP_006318939.1 NZ_CP015613:4297841-4298185 [Serratia inhibens PRI-2C]
MWQVITVERFDDWFLSLNGDEQKSLLAGIFKLQEFGPLLARPHADTLHFSGSIRHLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRLLPIAAMEFSHYLATQR

Download         Length: 345 bp

>T63264 NZ_CP015613:4297841-4298185 [Serratia inhibens PRI-2C]
ATGTGGCAGGTCATAACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGGCGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCGCGTCCGCATGCCGACACTCTGCATTTTTCAGGCTCAATAA
GGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGGGTGTTTTTCGCCTTTGATCCGCAACGGCAGGCG
GTACTGCTATGCGGTGGCGATAAAACCGGCGATAAACGCTTTTACCAGCGCCTGTTGCCTATCGCCGCCATGGAATTTTC
ACATTATCTGGCAACCCAGAGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11153.08 Da        Isoelectric Point: 10.1425

>AT63264 WP_006318938.1 NZ_CP015613:4298191-4298493 [Serratia inhibens PRI-2C]
MAKPLSNLIDKLDPTVVAAARQKAEKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGNEIKLSSLKRYIEAM
GGTLSLEVELPNGQHRRMTL

Download         Length: 303 bp

>AT63264 NZ_CP015613:4298191-4298493 [Serratia inhibens PRI-2C]
ATGGCCAAGCCTTTATCAAATCTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAACTGCGTCTGGCGATGCTGCGGGAAGAACTTGCGGTGTCTCAGGTCGAGCTGGCGAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAACGCGGTAACGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGCTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KVK6

Antitoxin

Source ID Structure

References