63263

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4022238..4023577 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name HipT Uniprot ID A0A1B1KUY5
Locus tag Q5A_RS18655 Protein ID WP_006318220.1
Coordinates 4022546..4023577 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1B1KUV7
Locus tag Q5A_RS18650 Protein ID WP_006318221.1
Coordinates 4022238..4022549 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS18620 4017490..4018290 - 801 WP_006318227.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
Q5A_RS18625 4018287..4019081 - 795 WP_006318226.1 hydroxyethylthiazole kinase -
Q5A_RS18630 4019278..4019703 + 426 WP_006318225.1 GNAT family N-acetyltransferase -
Q5A_RS18635 4019866..4021107 - 1242 WP_006318224.1 MFS transporter -
Q5A_RS18640 4021202..4021645 + 444 WP_006318223.1 helix-turn-helix transcriptional regulator -
Q5A_RS18645 4021906..4022253 + 348 WP_006318222.1 hypothetical protein -
Q5A_RS18650 4022238..4022549 + 312 WP_006318221.1 HipA N-terminal domain-containing protein Antitoxin
Q5A_RS18655 4022546..4023577 + 1032 WP_006318220.1 HipA domain-containing protein Toxin
Q5A_RS18660 4023639..4024400 + 762 WP_006318219.1 23S rRNA pseudouridine(2604) synthase RluF -
Q5A_RS18665 4024470..4027550 - 3081 WP_065506481.1 autotransporter domain-containing protein -
Q5A_RS18670 4027780..4028094 - 315 WP_006318086.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4022238..4038870 16632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 38579.37 Da        Isoelectric Point: 6.4191

>T63263 WP_006318220.1 NZ_CP015613:4022546-4023577 [Serratia inhibens PRI-2C]
MNPDRCLINLTPLKAPELITGYSKQGIKQLFGSAKIALTLPFTRREFIQELPERQKGMSISGYQPKLSLSLEEGELRVVN
NDGTYILKPSPEEYPHLAENEHATMTVMARLKFVVPPFGLIRFKADVDRPDELAFVIKRYDRIGPDRVRLHQEQLDGAMG
INDKYGYVDGKKDISYEKAAKFLNHTVSNGLHSKRDVFLRILYAYVLGNNDFHLRNLGIIHPENASPYVAPVYDFISVAP
YPAAFGEYLALPLLECEENDAGIAPGINSPYGEYIGVDFILLAEGMDVNPKLAKKWLAEVVKSHQLIIDTYTESHMPAEQ
REAVLSYVARRITLLGVTELKTA

Download         Length: 1032 bp

>T63263 NZ_CP015613:4022546-4023577 [Serratia inhibens PRI-2C]
ATGAATCCAGACCGCTGCCTGATCAACTTAACCCCGCTGAAAGCGCCGGAGCTGATAACAGGATATTCCAAACAAGGTAT
CAAGCAGCTGTTTGGCAGCGCCAAAATCGCGCTTACCTTGCCATTCACCCGCAGAGAGTTTATCCAGGAACTGCCTGAGC
GTCAGAAAGGCATGAGTATTTCCGGTTATCAACCTAAATTGTCACTTAGCCTCGAAGAAGGCGAGCTGCGCGTCGTAAAC
AATGACGGCACTTATATCCTCAAACCCTCACCGGAAGAGTACCCTCACCTGGCTGAAAATGAACACGCCACCATGACCGT
CATGGCGCGGTTGAAGTTCGTTGTTCCCCCTTTTGGCCTTATACGCTTTAAAGCAGATGTAGATCGCCCCGATGAGCTGG
CCTTTGTTATTAAAAGATATGACCGTATCGGCCCGGATCGGGTTCGTTTACATCAAGAGCAGCTTGATGGCGCCATGGGC
ATTAATGATAAATATGGCTACGTTGACGGCAAGAAAGACATAAGTTACGAAAAAGCGGCAAAGTTTTTGAATCATACGGT
CAGCAACGGCCTGCACAGTAAACGTGACGTTTTTTTACGTATCCTTTATGCCTATGTACTGGGTAATAATGACTTTCATC
TTCGCAACCTGGGCATCATACACCCTGAAAATGCATCGCCTTACGTCGCACCGGTCTATGACTTTATCAGCGTGGCCCCT
TACCCTGCAGCATTCGGGGAATATCTGGCATTGCCCCTGCTGGAATGCGAGGAAAACGATGCGGGCATTGCCCCCGGTAT
TAATTCCCCCTATGGCGAATACATTGGCGTCGACTTCATTCTTCTGGCAGAAGGCATGGACGTTAATCCAAAGCTGGCTA
AAAAGTGGCTGGCGGAAGTGGTGAAAAGCCATCAGCTGATTATTGACACTTATACCGAAAGCCATATGCCGGCAGAACAA
CGTGAAGCCGTGCTCAGTTATGTGGCAAGGAGAATAACCTTGCTTGGCGTGACCGAGCTTAAAACGGCGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11775.50 Da        Isoelectric Point: 5.8715

>AT63263 WP_006318221.1 NZ_CP015613:4022238-4022549 [Serratia inhibens PRI-2C]
MARKIEVWLYGKAVGSLTEEKEGYTFGYYSGYSGPAVSLSMRVRPEPYFSEELHPFFKGLAPEGWLRKRYAEIQKIDDRD
LFGLLMQNGNDLLGAVVFKEMSP

Download         Length: 312 bp

>AT63263 NZ_CP015613:4022238-4022549 [Serratia inhibens PRI-2C]
ATGGCTAGAAAGATAGAGGTCTGGCTTTACGGCAAAGCCGTGGGGAGCTTAACTGAAGAAAAAGAAGGGTATACCTTCGG
CTATTACTCAGGCTATAGCGGTCCGGCAGTGTCGCTTAGCATGCGCGTTCGGCCTGAACCCTATTTTAGCGAAGAGTTAC
ACCCATTTTTCAAAGGGTTGGCACCAGAAGGATGGTTACGCAAACGGTATGCCGAAATCCAAAAAATTGACGATCGGGAT
CTGTTCGGTTTACTGATGCAAAACGGTAACGACCTTCTCGGTGCCGTAGTTTTCAAAGAGATGAGCCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUY5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUV7

References