Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3998172..3998760 Replicon chromosome
Accession NZ_CP015612
Organism Stenotrophomonas maltophilia strain OUC_Est10

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag A7326_RS18365 Protein ID WP_088027234.1
Coordinates 3998482..3998760 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7326_RS18360 Protein ID WP_049463234.1
Coordinates 3998172..3998471 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7326_RS18340 3993634..3994821 + 1188 WP_088027224.1 pyridoxal phosphate-dependent aminotransferase -
A7326_RS18345 3994909..3997005 - 2097 WP_088027227.1 prolyl oligopeptidase family protein -
A7326_RS18350 3997075..3997401 - 327 WP_088027230.1 hypothetical protein -
A7326_RS18355 3997529..3998131 + 603 WP_088027232.1 lipocalin family protein -
A7326_RS18360 3998172..3998471 - 300 WP_049463234.1 HigA family addiction module antidote protein Antitoxin
A7326_RS18365 3998482..3998760 - 279 WP_088027234.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7326_RS18370 3999009..3999698 - 690 WP_014038544.1 ABC transporter permease -
A7326_RS18375 3999695..4000702 - 1008 WP_032129022.1 methionine ABC transporter ATP-binding protein -
A7326_RS18380 4000913..4001809 - 897 WP_088027236.1 DMT family transporter -
A7326_RS18385 4001996..4002478 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
A7326_RS18390 4002514..4003611 - 1098 WP_088028495.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10658.16 Da        Isoelectric Point: 9.8905

>T63244 WP_088027234.1 NZ_CP015612:c3998760-3998482 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCPRAWLSIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRKGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

>T63244 NZ_CP015612:c3998760-3998482 [Stenotrophomonas maltophilia]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGTGCCCTGTTTGAAGGAACCTGTCCACGTGCCTGGCTTTCGATCCGGCG
GGCTGCCGAGCGCAAACTCCAACTGCTCGACTCGGCACAGACGTTGGCATTCCTGCGCAGCCCGCCCGGAAACCGGCTCG
AAGCGCTGTCAGGTGACCGGAAAGGGCAGTACAGCCTTCGGATCAACGATCAGTGGCGGCTCTGCTTTACCTGGACCGAC
AACGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10916.62 Da        Isoelectric Point: 11.2297

>AT63244 WP_049463234.1 NZ_CP015612:c3998471-3998172 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLMPLALSVNALARALDVPATRLHAIVHGERSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT63244 NZ_CP015612:c3998471-3998172 [Stenotrophomonas maltophilia]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGATGCCTCTGGCGTT
GAGCGTGAACGCGCTGGCAAGGGCCTTGGATGTTCCCGCAACACGGCTGCACGCCATCGTGCACGGGGAGCGCAGTATTT
CGGCCGATACCGCGGCACGGCTGGCGCGACATTTTGGTGGGGATGCCGCGTCCTGGCTTGCGATGCAGGCGGCCTACGAC
CTCAAGACATTGCCAACGCGCAGCGAGATCGAGCGACGGGTGCAGCCGCGGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References