Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 159168..159753 | Replicon | plasmid unnamed |
| Accession | NZ_CP015595 | ||
| Organism | Acinetobacter sp. NCu2D-2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A172YU17 |
| Locus tag | A3K93_RS13885 | Protein ID | WP_067731908.1 |
| Coordinates | 159168..159488 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A3K93_RS13890 | Protein ID | WP_004641921.1 |
| Coordinates | 159481..159753 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A3K93_RS13840 | 154632..154892 | - | 261 | WP_005265047.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| A3K93_RS13845 | 154989..155417 | - | 429 | WP_067731899.1 | arsenate reductase (glutaredoxin) | - |
| A3K93_RS13850 | 155500..155814 | + | 315 | WP_067731901.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| A3K93_RS13855 | 155819..156859 | + | 1041 | WP_067731906.1 | ACR3 family arsenite efflux transporter | - |
| A3K93_RS13860 | 156865..157569 | + | 705 | WP_034583466.1 | arsenical resistance protein ArsH | - |
| A3K93_RS13865 | 157677..157967 | - | 291 | WP_004676242.1 | type II toxin-antitoxin system YafQ family toxin | - |
| A3K93_RS13870 | 157954..158214 | - | 261 | WP_005265047.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| A3K93_RS13875 | 158296..158805 | - | 510 | WP_067731907.1 | DinB family protein | - |
| A3K93_RS13880 | 158829..159048 | - | 220 | Protein_137 | hypothetical protein | - |
| A3K93_RS13885 | 159168..159488 | + | 321 | WP_067731908.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A3K93_RS13890 | 159481..159753 | + | 273 | WP_004641921.1 | helix-turn-helix domain-containing protein | Antitoxin |
| A3K93_RS13895 | 160674..160889 | + | 216 | WP_005237341.1 | cold-shock protein | - |
| A3K93_RS13900 | 160988..161215 | + | 228 | WP_067731910.1 | hypothetical protein | - |
| A3K93_RS13905 | 161284..161481 | + | 198 | WP_005237334.1 | hypothetical protein | - |
| A3K93_RS13910 | 161744..162289 | - | 546 | WP_005176794.1 | XRE family transcriptional regulator | - |
| A3K93_RS13915 | 162382..163260 | + | 879 | WP_067732190.1 | DMT family transporter | - |
| A3K93_RS13920 | 163339..163632 | - | 294 | WP_067731912.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| A3K93_RS13925 | 163622..163867 | - | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| A3K93_RS13930 | 163961..164488 | - | 528 | WP_000537572.1 | plasmid pRiA4b ORF-3 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..309964 | 309964 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12078.91 Da Isoelectric Point: 9.4139
>T63226 WP_067731908.1 NZ_CP015595:159168-159488 [Acinetobacter sp. NCu2D-2]
MLFIETSIFTKQIKGLVSGEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG
MLFIETSIFTKQIKGLVSGEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG
Download Length: 321 bp
>T63226 NZ_CP015595:159168-159488 [Acinetobacter sp. NCu2D-2]
ATGTTATTCATTGAGACCAGTATTTTTACTAAGCAAATCAAAGGGCTTGTGAGTGGTGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A
ATGTTATTCATTGAGACCAGTATTTTTACTAAGCAAATCAAAGGGCTTGTGAGTGGTGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A
Antitoxin
Download Length: 91 a.a. Molecular weight: 10108.56 Da Isoelectric Point: 7.2045
>AT63226 WP_004641921.1 NZ_CP015595:159481-159753 [Acinetobacter sp. NCu2D-2]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
Download Length: 273 bp
>AT63226 NZ_CP015595:159481-159753 [Acinetobacter sp. NCu2D-2]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAATGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAATGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|