Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 37277..37885 Replicon plasmid 2
Accession NZ_CP015586
Organism Roseomonas gilardii strain U14-5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RGI145_RS24205 Protein ID WP_075801083.1
Coordinates 37277..37561 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RGI145_RS24210 Protein ID WP_075801084.1
Coordinates 37574..37885 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGI145_RS24185 34305..34688 - 384 WP_156878781.1 hypothetical protein -
RGI145_RS24190 34908..35141 + 234 WP_075801080.1 helix-turn-helix transcriptional regulator -
RGI145_RS25340 35274..35747 - 474 WP_156878782.1 hypothetical protein -
RGI145_RS24200 36189..36839 + 651 WP_075801082.1 ParA family protein -
RGI145_RS24205 37277..37561 + 285 WP_075801083.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RGI145_RS24210 37574..37885 + 312 WP_075801084.1 HigA family addiction module antidote protein Antitoxin
RGI145_RS24855 38143..38909 + 767 WP_156878783.1 IS5 family transposase -
RGI145_RS25345 38915..39226 - 312 WP_156878784.1 hypothetical protein -
RGI145_RS24230 39393..40421 + 1029 WP_075801087.1 thymidylate synthase -
RGI145_RS24235 40418..41362 + 945 WP_075801088.1 hypothetical protein -
RGI145_RS24240 41352..42473 - 1122 WP_075801089.1 ImmA/IrrE family metallo-endopeptidase -
RGI145_RS24245 42466..42735 - 270 WP_156878785.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64339 64339
- flank IS/Tn - - 38143..38526 383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-89)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10846.38 Da        Isoelectric Point: 9.2045

>T63219 WP_075801083.1 NZ_CP015586:37277-37561 [Roseomonas gilardii]
VIQSFKDDATRRIFEGNRVFGVGWEQVQKIARRKLLMLHAAVVLDDLRSPPGNMLEPLQGNRAGQHSIRVNGQWRVCFVW
RPDGPHEVEVTDYH

Download         Length: 285 bp

>T63219 NZ_CP015586:37277-37561 [Roseomonas gilardii]
GTGATCCAGTCGTTTAAGGATGATGCCACCCGGCGCATCTTCGAGGGCAACCGCGTCTTCGGGGTGGGCTGGGAGCAGGT
CCAAAAGATCGCAAGGCGGAAGCTGCTCATGTTGCACGCTGCGGTGGTCTTGGACGATCTACGCAGCCCGCCAGGGAACA
TGTTGGAGCCGTTACAAGGCAACAGGGCTGGCCAGCACTCGATCCGGGTGAATGGCCAATGGCGGGTGTGCTTCGTGTGG
CGCCCGGACGGCCCCCATGAGGTCGAAGTGACGGACTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11437.88 Da        Isoelectric Point: 4.8499

>AT63219 WP_075801084.1 NZ_CP015586:37574-37885 [Roseomonas gilardii]
MVDRDLVIHPGEILMEEFLRPHGLTPSGFASRLDLPANRFTAIVNGERGISSETAVLLAAAFGTTEAFWLNLQSQYDLEQ
ARASVSPERVRKARDLHNEFEAA

Download         Length: 312 bp

>AT63219 NZ_CP015586:37574-37885 [Roseomonas gilardii]
ATGGTTGATCGTGACTTGGTGATCCATCCAGGCGAGATCCTGATGGAAGAGTTCCTGCGTCCGCACGGGCTGACGCCCAG
TGGCTTCGCGTCGCGCCTAGACCTGCCGGCGAACCGCTTCACTGCGATCGTCAATGGTGAGAGGGGCATCTCTTCTGAGA
CGGCCGTGCTGCTGGCGGCTGCCTTTGGCACCACGGAGGCATTCTGGCTGAACCTTCAGAGCCAGTACGACCTGGAGCAA
GCCAGGGCTTCCGTGTCCCCGGAGCGGGTCCGGAAGGCACGCGATCTGCATAACGAATTCGAGGCAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References