Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2571021..2571681 Replicon chromosome
Accession NZ_CP015581
Organism Tatumella citrea strain ATCC 39140

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A7K99_RS12250 Protein ID WP_087488819.1
Coordinates 2571337..2571681 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7K99_RS12245 Protein ID WP_087488818.1
Coordinates 2571021..2571323 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7K99_RS12220 2567156..2567833 - 678 WP_087488814.1 amino acid ABC transporter permease -
A7K99_RS12225 2567833..2568627 - 795 WP_087488815.1 amino acid ABC transporter ATP-binding protein -
A7K99_RS12230 2568633..2569418 - 786 WP_087488816.1 transporter substrate-binding domain-containing protein -
A7K99_RS12235 2569514..2570401 + 888 WP_087488817.1 LysR family transcriptional regulator -
A7K99_RS12245 2571021..2571323 - 303 WP_087488818.1 XRE family transcriptional regulator Antitoxin
A7K99_RS12250 2571337..2571681 - 345 WP_087488819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7K99_RS12255 2572621..2573541 + 921 WP_087488820.1 LysR family transcriptional regulator -
A7K99_RS12260 2573538..2575232 - 1695 WP_087488821.1 acetolactate synthase -
A7K99_RS12265 2575476..2576399 + 924 WP_087488822.1 PhzF family phenazine biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13169.23 Da        Isoelectric Point: 10.1014

>T63218 WP_087488819.1 NZ_CP015581:c2571681-2571337 [Tatumella citrea]
VWTVITTDRFDHWLCSLSDSARISVLAMLLVLREKGPGLSRPYADTVKGSRYNNMKELRIQHHGDPIRAFYAFDLARNGI
VLCAGNKVGNEKRFYAEMLPVADREFTRWLNRLK

Download         Length: 345 bp

>T63218 NZ_CP015581:c2571681-2571337 [Tatumella citrea]
GTGTGGACAGTTATCACCACGGATAGGTTCGATCACTGGTTATGCTCACTCAGCGATAGCGCCAGGATCAGCGTGCTTGC
CATGTTGTTAGTTTTGCGGGAAAAGGGGCCTGGCTTATCCAGACCTTATGCGGATACGGTGAAAGGTTCCCGTTACAACA
ATATGAAAGAGTTGCGTATTCAACATCACGGGGATCCCATCCGTGCATTTTACGCTTTTGATCTGGCGCGTAACGGTATT
GTGCTTTGTGCCGGAAACAAAGTCGGTAATGAAAAACGTTTTTATGCTGAGATGCTTCCGGTGGCTGACCGGGAATTCAC
TCGCTGGCTGAACAGATTAAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11151.02 Da        Isoelectric Point: 6.4709

>AT63218 WP_087488818.1 NZ_CP015581:c2571323-2571021 [Tatumella citrea]
MVRTLEQLIADEKPEVLAQAQAMANDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT63218 NZ_CP015581:c2571323-2571021 [Tatumella citrea]
ATGGTCAGAACGCTGGAACAGCTTATTGCAGATGAAAAACCTGAAGTGCTGGCCCAGGCACAGGCGATGGCAAATGATAT
TCTGCTCAATATCCACCTTGCCGAATTGCGTGAGAAAGTACAGAAAACTCAGGTGGAAATGGCACAGGCTTTGGGAATCA
GGCAACCCACTGTTGCTGTAATGGAGAAACCGGGGCGCGACCTGAAGCTTTCCACGCTCAAACGCTACGTTGAAGCGACC
GGCGGCAAACTCCGCCTTGATGTTGAACTGCCGGATGGTTCTCACTATGGATTTGTATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References