Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1514041..1514651 Replicon chromosome
Accession NZ_CP015581
Organism Tatumella citrea strain ATCC 39140

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A7K99_RS07200 Protein ID WP_087487933.1
Coordinates 1514340..1514651 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7K99_RS07195 Protein ID WP_087487932.1
Coordinates 1514041..1514340 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7K99_RS07165 1510597..1511145 + 549 WP_087487929.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
A7K99_RS07175 1511510..1512427 - 918 WP_087487930.1 LysR family transcriptional regulator -
A7K99_RS07180 1512680..1513309 + 630 WP_087487931.1 LysE family translocator -
A7K99_RS07195 1514041..1514340 - 300 WP_087487932.1 helix-turn-helix domain-containing protein Antitoxin
A7K99_RS07200 1514340..1514651 - 312 WP_087487933.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7K99_RS07205 1515016..1516365 - 1350 Protein_1375 IS3 family transposase -
A7K99_RS21250 1516490..1516666 - 177 WP_157665893.1 integrase -
A7K99_RS07210 1517390..1518070 + 681 WP_087490406.1 type 1 glutamine amidotransferase domain-containing protein -
A7K99_RS07215 1518161..1518916 + 756 WP_087487934.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12209.97 Da        Isoelectric Point: 8.3903

>T63217 WP_087487933.1 NZ_CP015581:c1514651-1514340 [Tatumella citrea]
MLFIETHIFTEDVKELLNDDEYREFQQFMADNPAWGDVIQNTGGLRKVRWAARGKGKRGGVRVIYYYKLSESQIRLLLIY
KKGIRDDLSEEEKRLLRALNEGW

Download         Length: 312 bp

>T63217 NZ_CP015581:c1514651-1514340 [Tatumella citrea]
ATGCTGTTTATTGAAACCCATATATTCACCGAAGATGTAAAGGAACTACTGAACGATGATGAATACCGCGAGTTTCAGCA
GTTCATGGCAGACAACCCTGCCTGGGGAGACGTGATTCAGAATACAGGTGGCCTGCGTAAGGTACGCTGGGCTGCCAGGG
GCAAAGGTAAACGTGGCGGTGTTCGGGTAATTTACTACTATAAACTATCCGAATCACAGATCCGACTTCTGCTCATCTAT
AAAAAAGGCATCAGGGATGATTTATCTGAGGAAGAAAAACGTTTGCTAAGGGCGTTGAATGAGGGCTGGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.55 Da        Isoelectric Point: 10.0103

>AT63217 WP_087487932.1 NZ_CP015581:c1514340-1514041 [Tatumella citrea]
MDKKLFERLTESMTQMNEIVEGSREPSRETTVTAVKVKAIRTATGLSQSGFAKLISVNVDTLKNWEQGRREPTGPAKALL
RAIERDPQHVIPALSPDTP

Download         Length: 300 bp

>AT63217 NZ_CP015581:c1514340-1514041 [Tatumella citrea]
ATGGACAAGAAACTGTTTGAGCGTCTGACAGAAAGTATGACGCAAATGAATGAAATCGTTGAGGGTTCACGTGAACCCTC
CCGTGAAACAACGGTTACCGCAGTTAAGGTCAAGGCAATCAGAACAGCCACCGGTCTTTCACAGAGTGGGTTCGCGAAAC
TGATTTCAGTGAATGTTGACACGCTGAAGAACTGGGAACAGGGACGACGCGAACCCACCGGACCGGCAAAAGCATTGCTG
AGAGCGATAGAACGCGATCCTCAGCATGTGATCCCGGCACTTTCTCCTGATACACCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References