Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1514368..1514978 Replicon chromosome
Accession NZ_CP015579
Organism Tatumella citrea strain DSM 13699

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A7K98_RS07205 Protein ID WP_087487933.1
Coordinates 1514667..1514978 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7K98_RS07200 Protein ID WP_087487932.1
Coordinates 1514368..1514667 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7K98_RS07170 1510924..1511472 + 549 WP_087487929.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
A7K98_RS07180 1511837..1512754 - 918 WP_087487930.1 LysR family transcriptional regulator -
A7K98_RS07185 1513007..1513636 + 630 WP_087487931.1 LysE family translocator -
A7K98_RS07200 1514368..1514667 - 300 WP_087487932.1 helix-turn-helix domain-containing protein Antitoxin
A7K98_RS07205 1514667..1514978 - 312 WP_087487933.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7K98_RS07210 1515343..1516693 - 1351 Protein_1376 IS3 family transposase -
A7K98_RS21275 1516818..1516994 - 177 WP_157665893.1 integrase -
A7K98_RS07215 1517718..1518398 + 681 WP_087490406.1 type 1 glutamine amidotransferase domain-containing protein -
A7K98_RS07220 1518489..1519244 + 756 WP_087487934.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12209.97 Da        Isoelectric Point: 8.3903

>T63212 WP_087487933.1 NZ_CP015579:c1514978-1514667 [Tatumella citrea]
MLFIETHIFTEDVKELLNDDEYREFQQFMADNPAWGDVIQNTGGLRKVRWAARGKGKRGGVRVIYYYKLSESQIRLLLIY
KKGIRDDLSEEEKRLLRALNEGW

Download         Length: 312 bp

>T63212 NZ_CP015579:c1514978-1514667 [Tatumella citrea]
ATGCTGTTTATTGAAACCCATATATTCACCGAAGATGTAAAGGAACTACTGAACGATGATGAATACCGCGAGTTTCAGCA
GTTCATGGCAGACAACCCTGCCTGGGGAGACGTGATTCAGAATACAGGTGGCCTGCGTAAGGTACGCTGGGCTGCCAGGG
GCAAAGGTAAACGTGGCGGTGTTCGGGTAATTTACTACTATAAACTATCCGAATCACAGATCCGACTTCTGCTCATCTAT
AAAAAAGGCATCAGGGATGATTTATCTGAGGAAGAAAAACGTTTGCTAAGGGCGTTGAATGAGGGCTGGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.55 Da        Isoelectric Point: 10.0103

>AT63212 WP_087487932.1 NZ_CP015579:c1514667-1514368 [Tatumella citrea]
MDKKLFERLTESMTQMNEIVEGSREPSRETTVTAVKVKAIRTATGLSQSGFAKLISVNVDTLKNWEQGRREPTGPAKALL
RAIERDPQHVIPALSPDTP

Download         Length: 300 bp

>AT63212 NZ_CP015579:c1514667-1514368 [Tatumella citrea]
ATGGACAAGAAACTGTTTGAGCGTCTGACAGAAAGTATGACGCAAATGAATGAAATCGTTGAGGGTTCACGTGAACCCTC
CCGTGAAACAACGGTTACCGCAGTTAAGGTCAAGGCAATCAGAACAGCCACCGGTCTTTCACAGAGTGGGTTCGCGAAAC
TGATTTCAGTGAATGTTGACACGCTGAAGAACTGGGAACAGGGACGACGCGAACCCACCGGACCGGCAAAAGCATTGCTG
AGAGCGATAGAACGCGATCCTCAGCATGTGATCCCGGCACTTTCTCCTGATACACCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References