Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1964187..1964706 Replicon chromosome
Accession NZ_CP015557
Organism Streptococcus suis strain DN13

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8K9K9
Locus tag A6M16_RS09595 Protein ID WP_015647467.1
Coordinates 1964187..1964444 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag A6M16_RS09600 Protein ID WP_002939010.1
Coordinates 1964446..1964706 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6M16_RS09580 1960820..1962550 - 1731 WP_024395751.1 membrane protein -
A6M16_RS09585 1962751..1963659 - 909 WP_079266809.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
A6M16_RS09590 1963643..1964173 - 531 WP_024388538.1 DUF1697 domain-containing protein -
A6M16_RS09595 1964187..1964444 - 258 WP_015647467.1 Txe/YoeB family addiction module toxin Toxin
A6M16_RS09600 1964446..1964706 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6M16_RS09605 1964782..1965237 - 456 WP_024395752.1 8-oxo-dGTP diphosphatase -
A6M16_RS09610 1965241..1965609 - 369 WP_024395753.1 hypothetical protein -
A6M16_RS09615 1965602..1966192 - 591 WP_172054615.1 ribonuclease M5 -
A6M16_RS09620 1966155..1966937 - 783 WP_024395755.1 TatD family hydrolase -
A6M16_RS09625 1967044..1967181 - 138 WP_002939016.1 50S ribosomal protein L34 -
A6M16_RS09630 1967349..1968344 - 996 WP_024395756.1 protein jag -
A6M16_RS09635 1968364..1969176 - 813 WP_024395757.1 YidC/Oxa1 family membrane protein insertase -
A6M16_RS09640 1969160..1969519 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10378.92 Da        Isoelectric Point: 8.0279

>T63190 WP_015647467.1 NZ_CP015557:c1964444-1964187 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMMEADRLCILSL
KDHYR

Download         Length: 258 bp

>T63190 NZ_CP015557:c1964444-1964187 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGATGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT63190 WP_002939010.1 NZ_CP015557:c1964706-1964446 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT63190 NZ_CP015557:c1964706-1964446 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAAGACTATATGAAAAAGGTCAATGACGAGTTTGAGCCCTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8K9K9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References