Detailed information of TA system TA063188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 700619..701273
• Replicon: chromosome
• Accession: NZ_CP015557
• Organism: Streptococcus suis strain DN13

Toxin (Protein)

• Gene name: higB
• Uniprot ID: G7SDV0
• Locus tag: A6M16_RS03550
• Protein ID: WP_014637766.1
• Coordinates: 700619..700984 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: G7SDV1
• Locus tag: A6M16_RS03555
• Protein ID: WP_014637767.1
• Coordinates: 700974..701273 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6M16_RS03535	696808..697401	-	594	WP_024395872.1	DUF1361 domain-containing protein	-
A6M16_RS03540	697557..699560	+	2004	WP_024395873.1	methionine--tRNA ligase	-
A6M16_RS03545	699622..700575	+	954	WP_024395874.1	competence protein CoiA	-
A6M16_RS03550	700619..700984	+	366	WP_014637766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6M16_RS03555	700974..701273	+	300	WP_014637767.1	helix-turn-helix transcriptional regulator	Antitoxin
A6M16_RS03560	701383..703185	+	1803	WP_024395875.1	oligoendopeptidase F	-
A6M16_RS03565	703187..703630	+	444	WP_024395876.1	hypothetical protein	-
A6M16_RS03570	703641..704189	+	549	WP_024395877.1	hypothetical protein	-
A6M16_RS03575	704264..704983	+	720	WP_050573105.1	O-methyltransferase	-
A6M16_RS03580	705045..706046	+	1002	WP_024385839.1	peptidylprolyl isomerase PrsA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14435.66 Da
• Isoelectric Point: 10.1354

>T63188 WP_014637766.1 NZ_CP015557:700619-700984 [Streptococcus suis]
MYTIYFYKDKNGREPVLEYLRELASKKGKDSRIKLNKINDYIELLSQLGTQIGEPYVKHLEGNIWELRPLRDRILFVAWY
DGSFVLLHHFVKRSQKTPRRELEKAQRELADLKERGINNGK

Nucleotide

• Length: 366 bp

>T63188 NZ_CP015557:700619-700984 [Streptococcus suis]
ATGTACACTATTTATTTTTATAAGGATAAAAATGGAAGGGAGCCTGTTTTAGAGTATCTGAGGGAGCTTGCATCTAAAAA
GGGGAAAGATAGCAGGATTAAATTGAATAAGATAAATGATTATATTGAACTTTTAAGTCAACTGGGAACTCAAATTGGTG
AACCATATGTGAAGCACTTGGAAGGTAATATTTGGGAATTGCGTCCCTTAAGAGATAGGATTTTATTTGTCGCATGGTAT
GATGGGAGTTTTGTTTTACTGCATCATTTTGTGAAACGGTCACAGAAAACACCACGGAGGGAGCTTGAAAAGGCTCAACG
TGAGCTGGCAGACTTGAAAGAAAGGGGTATTAACAATGGAAAATAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11058.73 Da
• Isoelectric Point: 7.2059

>AT63188 WP_014637767.1 NZ_CP015557:700974-701273 [Streptococcus suis]
MENSAIGSNWQSVRSELFSEKEIIESDLRVAIMSELIKARHEQGVSQKRLEELSGVSQPVIARMETGKTSPQLDTILKVL
ASLGKTLAVVPLKQERHFQ

Nucleotide

• Length: 300 bp

>AT63188 NZ_CP015557:700974-701273 [Streptococcus suis]
ATGGAAAATAGTGCAATTGGTAGTAACTGGCAATCGGTACGGTCTGAACTCTTCAGTGAGAAGGAAATCATAGAAAGTGA
TTTGCGTGTGGCAATTATGAGCGAACTGATAAAAGCAAGGCATGAACAGGGAGTAAGTCAGAAAAGACTAGAGGAGCTAA
GCGGGGTGAGTCAACCAGTTATTGCAAGAATGGAAACAGGTAAAACTAGTCCACAATTGGACACTATCTTGAAGGTATTG
GCTAGTCTAGGCAAAACTTTAGCAGTTGTGCCTTTGAAACAGGAACGACATTTTCAATAG

Structures

Toxin

• AlphaFold DB: G7SDV0

Antitoxin

• AlphaFold DB: G7SDV1