Detailed information of TA system TA063182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 268256..268766
• Replicon: chromosome
• Accession: NZ_CP015553
• Organism: Staphylococcus carnosus strain TMW 2.1596

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: A2I68_RS01395
• Protein ID: WP_169929359.1
• Coordinates: 268512..268766 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B9DKQ3
• Locus tag: A2I68_RS01390
• Protein ID: WP_012664283.1
• Coordinates: 268256..268504 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2I68_RS01370 (A2I68_01335)	264442..264954	+	513	WP_012664280.1	YwhD family protein	-
A2I68_RS01375 (A2I68_01340)	265138..265755	-	618	WP_046100215.1	LysE family transporter	-
A2I68_RS01380 (A2I68_01345)	265962..266201	-	240	WP_231635373.1	fatty acid desaturase	-
A2I68_RS01385 (A2I68_01355)	266505..267916	+	1412	Protein_255	PLP-dependent aminotransferase family protein	-
A2I68_RS01390 (A2I68_01360)	268256..268504	+	249	WP_012664283.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A2I68_RS01395	268512..268766	+	255	WP_169929359.1	Txe/YoeB family addiction module toxin	Toxin
A2I68_RS01400 (A2I68_01365)	269254..270444	+	1191	WP_046100212.1	amidohydrolase	-
A2I68_RS01405 (A2I68_01370)	270605..271021	+	417	WP_046100211.1	DUF1934 family protein	-
A2I68_RS01410 (A2I68_01375)	271023..272687	+	1665	WP_012664287.1	arginine--tRNA ligase	-
A2I68_RS01415 (A2I68_01380)	272819..273721	+	903	WP_046100210.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9914.30 Da
• Isoelectric Point: 9.8956

>T63182 WP_169929359.1 NZ_CP015553:268512-268766 [Staphylococcus carnosus]
ISFSPEVFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESILAASCK
YHYQ

Nucleotide

• Length: 255 bp

>T63182 NZ_CP015553:268512-268766 [Staphylococcus carnosus]
ATTTCATTTTCTCCTGAAGTATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTGGAAGAAAATCAATCA
ATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAGGTGGTTTCAGTGGTT
GGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTAGCTGCTTCATGCAAG
TATCATTATCAATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9305.30 Da
• Isoelectric Point: 4.2081

>AT63182 WP_012664283.1 NZ_CP015553:268256-268504 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Nucleotide

• Length: 249 bp

>AT63182 NZ_CP015553:268256-268504 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380F8S2