Detailed information of TA system TA063181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2346329..2346839
• Replicon: chromosome
• Accession: NZ_CP015552
• Organism: Staphylococcus carnosus strain TMW 2.1538

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: A7E59_RS11655
• Protein ID: WP_169929359.1
• Coordinates: 2346329..2346583 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B9DKQ3
• Locus tag: A7E59_RS11660
• Protein ID: WP_012664283.1
• Coordinates: 2346591..2346839 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7E59_RS11635 (A7E59_11405)	2341374..2342276	-	903	WP_046100210.1	ABC transporter substrate-binding protein	-
A7E59_RS11640 (A7E59_11410)	2342408..2344072	-	1665	WP_012664287.1	arginine--tRNA ligase	-
A7E59_RS11645 (A7E59_11415)	2344074..2344490	-	417	WP_046100211.1	DUF1934 family protein	-
A7E59_RS11650 (A7E59_11420)	2344651..2345841	-	1191	WP_046100212.1	amidohydrolase	-
A7E59_RS11655	2346329..2346583	-	255	WP_169929359.1	Txe/YoeB family addiction module toxin	Toxin
A7E59_RS11660 (A7E59_11425)	2346591..2346839	-	249	WP_012664283.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A7E59_RS11665 (A7E59_11430)	2347179..2348590	-	1412	Protein_2271	PLP-dependent aminotransferase family protein	-
A7E59_RS11670 (A7E59_11440)	2348894..2349133	+	240	WP_231635373.1	fatty acid desaturase	-
A7E59_RS11675 (A7E59_11445)	2349340..2349957	+	618	WP_046100215.1	LysE family transporter	-
A7E59_RS11680 (A7E59_11450)	2350141..2350653	-	513	WP_012664280.1	YwhD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9914.30 Da
• Isoelectric Point: 9.8956

>T63181 WP_169929359.1 NZ_CP015552:c2346583-2346329 [Staphylococcus carnosus]
ISFSPEVFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESILAASCK
YHYQ

Nucleotide

• Length: 255 bp

>T63181 NZ_CP015552:c2346583-2346329 [Staphylococcus carnosus]
ATTTCATTTTCTCCTGAAGTATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTGGAAGAAAATCAATCA
ATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAGGTGGTTTCAGTGGTT
GGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTAGCTGCTTCATGCAAG
TATCATTATCAATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9305.30 Da
• Isoelectric Point: 4.2081

>AT63181 WP_012664283.1 NZ_CP015552:c2346839-2346591 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Nucleotide

• Length: 249 bp

>AT63181 NZ_CP015552:c2346839-2346591 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380F8S2