63175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2302598..2303108 Replicon chromosome
Accession NZ_CP015536
Organism Staphylococcus carnosus strain TMW 2.243

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag A2I63_RS11305 Protein ID WP_012664284.1
Coordinates 2302598..2302867 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag A2I63_RS11310 Protein ID WP_012664283.1
Coordinates 2302860..2303108 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I63_RS11285 (A2I63_11125) 2297644..2298546 - 903 WP_012664288.1 ABC transporter substrate-binding protein -
A2I63_RS11290 (A2I63_11130) 2298678..2300342 - 1665 WP_012664287.1 arginine--tRNA ligase -
A2I63_RS11295 (A2I63_11135) 2300344..2300760 - 417 WP_012664286.1 DUF1934 family protein -
A2I63_RS11300 (A2I63_11140) 2300921..2302111 - 1191 WP_012664285.1 amidohydrolase -
A2I63_RS11305 (A2I63_11145) 2302598..2302867 - 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
A2I63_RS11310 (A2I63_11150) 2302860..2303108 - 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A2I63_RS11315 (A2I63_11155) 2303448..2304860 - 1413 WP_012664282.1 PLP-dependent aminotransferase family protein -
A2I63_RS11320 2305164..2305403 + 240 WP_231635373.1 fatty acid desaturase -
A2I63_RS11325 (A2I63_11165) 2305610..2306227 + 618 WP_012664281.1 LysE family transporter -
A2I63_RS11330 (A2I63_11170) 2306411..2306923 - 513 WP_012664280.1 YwhD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T63175 WP_012664284.1 NZ_CP015536:c2302867-2302598 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T63175 NZ_CP015536:c2302867-2302598 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT63175 WP_012664283.1 NZ_CP015536:c2303108-2302860 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT63175 NZ_CP015536:c2303108-2302860 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References