Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2375966..2376476 Replicon chromosome
Accession NZ_CP015535
Organism Staphylococcus carnosus strain TMW 2.218

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag A2I66_RS11845 Protein ID WP_012664284.1
Coordinates 2375966..2376235 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag A2I66_RS11850 Protein ID WP_012664283.1
Coordinates 2376228..2376476 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I66_RS11825 (A2I66_11615) 2371012..2371914 - 903 WP_053464280.1 ABC transporter substrate-binding protein -
A2I66_RS11830 (A2I66_11620) 2372046..2373710 - 1665 WP_065865778.1 arginine--tRNA ligase -
A2I66_RS11835 (A2I66_11625) 2373712..2374128 - 417 WP_046100211.1 DUF1934 family protein -
A2I66_RS11840 (A2I66_11630) 2374289..2375479 - 1191 WP_065865779.1 amidohydrolase -
A2I66_RS11845 (A2I66_11635) 2375966..2376235 - 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
A2I66_RS11850 (A2I66_11640) 2376228..2376476 - 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A2I66_RS11855 (A2I66_11645) 2376816..2378227 - 1412 Protein_2308 PLP-dependent aminotransferase family protein -
A2I66_RS11860 2378531..2378770 + 240 WP_231635373.1 fatty acid desaturase -
A2I66_RS11865 (A2I66_11655) 2378977..2379594 + 618 WP_012664281.1 LysE family transporter -
A2I66_RS11870 (A2I66_11660) 2379778..2380290 - 513 WP_012664280.1 YwhD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T63172 WP_012664284.1 NZ_CP015535:c2376235-2375966 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T63172 NZ_CP015535:c2376235-2375966 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT63172 WP_012664283.1 NZ_CP015535:c2376476-2376228 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT63172 NZ_CP015535:c2376476-2376228 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References