Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2350314..2350824 Replicon chromosome
Accession NZ_CP015532
Organism Staphylococcus carnosus strain TMW 2.212

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag A2I65_RS11625 Protein ID WP_012664284.1
Coordinates 2350314..2350583 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag A2I65_RS11630 Protein ID WP_012664283.1
Coordinates 2350576..2350824 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I65_RS11605 (A2I65_11400) 2345360..2346262 - 903 WP_253720245.1 ABC transporter substrate-binding protein -
A2I65_RS11610 (A2I65_11405) 2346394..2348058 - 1665 WP_253720246.1 arginine--tRNA ligase -
A2I65_RS11615 (A2I65_11410) 2348060..2348476 - 417 WP_046100211.1 DUF1934 family protein -
A2I65_RS11620 (A2I65_11415) 2348637..2349827 - 1191 WP_253720247.1 amidohydrolase -
A2I65_RS11625 (A2I65_11420) 2350314..2350583 - 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
A2I65_RS11630 (A2I65_11425) 2350576..2350824 - 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A2I65_RS11635 (A2I65_11430) 2351164..2352576 - 1413 WP_253720248.1 PLP-dependent aminotransferase family protein -
A2I65_RS11640 2352880..2353119 + 240 WP_231635373.1 fatty acid desaturase -
A2I65_RS11645 (A2I65_11440) 2353326..2353943 + 618 WP_012664281.1 LysE family transporter -
A2I65_RS11650 (A2I65_11445) 2354127..2354639 - 513 WP_012664280.1 YwhD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T63163 WP_012664284.1 NZ_CP015532:c2350583-2350314 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T63163 NZ_CP015532:c2350583-2350314 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT63163 WP_012664283.1 NZ_CP015532:c2350824-2350576 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT63163 NZ_CP015532:c2350824-2350576 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References