63096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2734804..2735327 Replicon chromosome
Accession NZ_CP015447
Organism Staphylococcus aureus strain M92

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag A6V38_RS14580 Protein ID WP_000074048.1
Coordinates 2734804..2735070 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag A6V38_RS14585 Protein ID WP_000587616.1
Coordinates 2735070..2735327 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V38_RS14560 2730111..2731298 - 1188 WP_000026194.1 MFS transporter -
A6V38_RS14565 2731694..2732470 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
A6V38_RS14570 2732463..2733125 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
A6V38_RS14575 2733373..2734449 - 1077 WP_001076671.1 M42 family metallopeptidase -
A6V38_RS14580 2734804..2735070 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
A6V38_RS14585 2735070..2735327 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6V38_RS14590 2735433..2735627 - 195 WP_001790145.1 hypothetical protein -
A6V38_RS14595 2735686..2736141 + 456 WP_000732080.1 DUF1307 domain-containing protein -
A6V38_RS14600 2736309..2737886 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
A6V38_RS14605 2738081..2738830 + 750 WP_000072442.1 hypothetical protein -
A6V38_RS14610 2739054..2740247 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T63096 WP_000074048.1 NZ_CP015447:c2735070-2734804 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T63096 NZ_CP015447:c2735070-2734804 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT63096 WP_000587616.1 NZ_CP015447:c2735327-2735070 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT63096 NZ_CP015447:c2735327-2735070 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References