Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2413001..2413280 Replicon chromosome
Accession NZ_CP015447
Organism Staphylococcus aureus strain M92

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A6V38_RS12835 Protein ID WP_001802298.1
Coordinates 2413176..2413280 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2413001..2413180 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V38_RS12815 2409200..2409865 - 666 WP_001024094.1 SDR family oxidoreductase -
A6V38_RS12820 2410017..2410337 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
A6V38_RS12825 2410339..2411319 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
A6V38_RS12830 2411585..2412676 + 1092 WP_000495671.1 lytic regulatory protein -
- 2413001..2413180 + 180 - - Antitoxin
A6V38_RS12835 2413176..2413280 - 105 WP_001802298.1 hypothetical protein Toxin
A6V38_RS16100 2413441..2413924 - 484 Protein_2379 recombinase family protein -
A6V38_RS12845 2413967..2415103 - 1137 WP_000115564.1 SAP domain-containing protein -
A6V38_RS12850 2415392..2415484 + 93 WP_001790138.1 hypothetical protein -
A6V38_RS12855 2416189..2417046 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
A6V38_RS12860 2417114..2417896 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T63089 WP_001802298.1 NZ_CP015447:c2413280-2413176 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T63089 NZ_CP015447:c2413280-2413176 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 180 bp

>AT63089 NZ_CP015447:2413001-2413180 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References