Detailed information of TA system TA063082

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2112138..2112437
• Replicon: chromosome
• Accession: NZ_CP015447
• Organism: Staphylococcus aureus strain M92

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A6V38_RS11050
• Protein ID: WP_072353918.1
• Coordinates: 2112261..2112437 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2112138..2112193 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6V38_RS10995	2107167..2107517	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
A6V38_RS11005	2107689..2108861	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
A6V38_RS11010	2109360..2109695	-	336	Protein_2028	SH3 domain-containing protein	-
A6V38_RS11030	2110346..2110837	-	492	WP_000920038.1	staphylokinase	-
A6V38_RS11035	2111028..2111783	-	756	WP_000861038.1	CHAP domain-containing protein	-
A6V38_RS11040	2111795..2112049	-	255	WP_000611512.1	phage holin	-
A6V38_RS11045	2112101..2112208	+	108	WP_001791821.1	hypothetical protein	-
-	2112130..2112269	+	140	NuclAT_0	-	-
-	2112130..2112269	+	140	NuclAT_0	-	-
-	2112130..2112269	+	140	NuclAT_0	-	-
-	2112130..2112269	+	140	NuclAT_0	-	-
-	2112138..2112193	+	56	-	-	Antitoxin
A6V38_RS11050	2112261..2112437	-	177	WP_072353918.1	putative holin-like toxin	Toxin
A6V38_RS11055	2112580..2112954	-	375	WP_000340977.1	hypothetical protein	-
A6V38_RS11060	2113010..2113297	-	288	WP_001262620.1	hypothetical protein	-
A6V38_RS11065	2113343..2113495	-	153	WP_001000058.1	hypothetical protein	-
A6V38_RS11070	2113488..2117270	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2107167..2166875	59708
	-	flank	IS/Tn	-	-	2107689..2108861	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T63082 WP_072353918.1 NZ_CP015447:c2112437-2112261 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T63082 NZ_CP015447:c2112437-2112261 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT63082 NZ_CP015447:2112138-2112193 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin