Detailed information of TA system TA063046

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 307721..308058
• Replicon: chromosome
• Accession: NZ_CP015410
• Organism: Enterococcus faecalis strain KB1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: A4V06_RS01455
• Protein ID: WP_002381035.1
• Coordinates: 307721..307864 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	307796..308058 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4V06_RS01435	302840..303055	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
A4V06_RS01440	303194..304186	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
A4V06_RS01445	304450..305088	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
A4V06_RS01450	305773..307389	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
A4V06_RS01455	307721..307864	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	307796..308058	-	263	-	-	Antitoxin
A4V06_RS01460	308059..312750	-	4692	WP_065536149.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T63046 WP_002381035.1 NZ_CP015410:307721-307864 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T63046 NZ_CP015410:307721-307864 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT63046 NZ_CP015410:c308058-307796 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin