Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 307485..307864 Replicon chromosome
Accession NZ_CP015410
Organism Enterococcus faecalis strain KB1

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag A4V06_RS01455 Protein ID WP_002381035.1
Coordinates 307721..307864 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 307485..307548 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4V06_RS01435 302840..303055 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
A4V06_RS01440 303194..304186 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
A4V06_RS01445 304450..305088 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
A4V06_RS01450 305773..307389 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
- 307485..307548 - 64 - - Antitoxin
A4V06_RS01455 307721..307864 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 308008..308057 + 50 - - -
A4V06_RS01460 308059..312750 - 4692 WP_065536149.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T63043 WP_002381035.1 NZ_CP015410:307721-307864 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T63043 NZ_CP015410:307721-307864 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 64 bp

>AT63043 NZ_CP015410:c307548-307485 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References