Detailed information of TA system TA063038

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 157623..157907
• Replicon: chromosome
• Accession: NZ_CP015410
• Organism: Enterococcus faecalis strain KB1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A4V06_RS00750
• Protein ID: WP_002386265.1
• Coordinates: 157779..157907 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	157623..157830 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4V06_RS00725	153307..154260	-	954	WP_002361029.1	siderophore ABC transporter substrate-binding protein	-
A4V06_RS00730	154299..155054	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
A4V06_RS00735	155051..156016	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
A4V06_RS00740	156013..156960	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
A4V06_RS00745	157145..157597	+	453	WP_002359057.1	YueI family protein	-
A4V06_RS00750	157779..157907	-	129	WP_002386265.1	hypothetical protein	Toxin
A4V06_RS00755	158069..160339	-	2271	WP_002380953.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
A4V06_RS00760	160510..161010	+	501	WP_002380954.1	cysteine hydrolase	-
A4V06_RS00765	161462..162358	+	897	WP_002365354.1	YitT family protein	-
A4V06_RS00770	162409..162807	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T63038 WP_002386265.1 NZ_CP015410:c157907-157779 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T63038 NZ_CP015410:c157907-157779 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT63038 NZ_CP015410:157623-157830 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin