Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1832660..1833267 Replicon chromosome
Accession NZ_CP015381
Organism Desulfococcus multivorans strain DSM 2059

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag dmul_RS19705 Protein ID WP_078081377.1
Coordinates 1832986..1833267 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag dmul_RS07925 Protein ID WP_020875561.1
Coordinates 1832660..1832974 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dmul_RS07895 1828426..1828878 + 453 WP_078081234.1 RidA family protein -
dmul_RS07900 1828888..1829733 + 846 WP_020875556.1 PhzF family phenazine biosynthesis protein -
dmul_RS07905 1829869..1830285 - 417 WP_020875557.1 type II toxin-antitoxin system HicB family antitoxin -
dmul_RS19700 1830295..1830483 - 189 WP_078081235.1 type II toxin-antitoxin system HicA family toxin -
dmul_RS07910 1830630..1831769 + 1140 WP_020875558.1 NADH:flavin oxidoreductase -
dmul_RS07915 1831889..1832131 + 243 WP_020875559.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
dmul_RS07920 1832125..1832391 + 267 WP_040414299.1 Txe/YoeB family addiction module toxin -
dmul_RS07925 1832660..1832974 - 315 WP_020875561.1 HigA family addiction module antidote protein Antitoxin
dmul_RS19705 1832986..1833267 - 282 WP_078081377.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
dmul_RS07930 1833628..1834113 + 486 WP_020875562.1 DUF1772 domain-containing protein -
dmul_RS07935 1834417..1835040 + 624 WP_040414325.1 hydrolase -
dmul_RS07940 1835195..1835680 + 486 WP_020875564.1 group 1 truncated hemoglobin -
dmul_RS07950 1836356..1837045 + 690 WP_040414326.1 aquaporin Z -
dmul_RS07955 1837098..1838180 + 1083 WP_020875566.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.58 Da        Isoelectric Point: 10.0490

>T62970 WP_078081377.1 NZ_CP015381:c1833267-1832986 [Desulfococcus multivorans]
MIKTFADKETQQLFVSGKSKRLPSDLLRRAIRRLEFIHFANDIKDLLVPRSNRLHALKGDRKGQHSISINDQWRICFRFI
EGDAYDVEVTDYH

Download         Length: 282 bp

>T62970 NZ_CP015381:c1833267-1832986 [Desulfococcus multivorans]
ATGATAAAAACATTTGCCGATAAAGAAACCCAGCAATTATTTGTTTCCGGCAAATCGAAACGCTTACCATCCGATTTATT
ACGAAGGGCAATAAGACGTTTAGAATTTATTCACTTTGCAAATGACATAAAAGACCTTTTGGTGCCACGCAGCAACAGGC
TCCATGCGCTTAAAGGCGACAGGAAAGGGCAACACTCAATATCGATAAATGACCAGTGGCGAATATGTTTCCGTTTCATT
GAAGGCGATGCCTACGATGTTGAGGTTACCGATTACCATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12044.70 Da        Isoelectric Point: 8.6052

>AT62970 WP_020875561.1 NZ_CP015381:c1832974-1832660 [Desulfococcus multivorans]
MAIPNTTKREIKPTHPGEMLREDFMPDYDLNTASMANALGVSRQTINEILRERRAISPAMALRLSRLFSNSPEFWLNAQH
SWDLWDSEKRYSKELSQIRPLNAA

Download         Length: 315 bp

>AT62970 NZ_CP015381:c1832974-1832660 [Desulfococcus multivorans]
ATGGCTATACCCAATACGACAAAGCGTGAAATTAAGCCGACTCATCCCGGTGAAATGCTTAGAGAGGATTTCATGCCGGA
CTATGATCTGAACACGGCTTCCATGGCAAACGCATTAGGCGTGTCACGCCAAACAATTAATGAAATTTTGAGAGAACGAC
GTGCTATCAGTCCGGCTATGGCGCTAAGATTATCTCGACTTTTCAGCAATTCACCGGAATTCTGGCTGAATGCCCAGCAT
TCGTGGGACCTTTGGGATTCGGAAAAACGCTACAGTAAAGAATTGTCTCAAATCCGACCCTTGAATGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References