Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1832660..1833267 Replicon chromosome
Accession NZ_CP015381
Organism Desulfococcus multivorans strain DSM 2059

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag dmul_RS19705 Protein ID WP_078081377.1
Coordinates 1832986..1833267 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag dmul_RS07925 Protein ID WP_020875561.1
Coordinates 1832660..1832974 (-) Length 105 a.a.

Genomic Context

dmul_RS07895dmul_RS07900dmul_RS07910dmul_RS07915dmul_RS07920dmul_RS07930dmul_RS07935dmul_RS07940dmul_RS07950dmul_RS07955dmul_RS07905dmul_RS19700dmul_RS07925dmul_RS19705
Location: 1828426..1828878 (453 bp)
Type: Others
Protein ID: WP_078081234.1
Location: 1828888..1829733 (846 bp)
Type: Others
Protein ID: WP_020875556.1
Location: 1830630..1831769 (1140 bp)
Type: Others
Protein ID: WP_020875558.1
Location: 1831889..1832131 (243 bp)
Type: Others
Protein ID: WP_020875559.1
Location: 1832125..1832391 (267 bp)
Type: Others
Protein ID: WP_040414299.1
Location: 1833628..1834113 (486 bp)
Type: Others
Protein ID: WP_020875562.1
Location: 1834417..1835040 (624 bp)
Type: Others
Protein ID: WP_040414325.1
Location: 1835195..1835680 (486 bp)
Type: Others
Protein ID: WP_020875564.1
Location: 1836356..1837045 (690 bp)
Type: Others
Protein ID: WP_040414326.1
Location: 1837098..1838180 (1083 bp)
Type: Others
Protein ID: WP_020875566.1
Location: 1829869..1830285 (417 bp)
Type: Others
Protein ID: WP_020875557.1
Location: 1830295..1830483 (189 bp)
Type: Others
Protein ID: WP_078081235.1
Location: 1832660..1832974 (315 bp)
Type: Antitoxin
Protein ID: WP_020875561.1
Location: 1832986..1833267 (282 bp)
Type: Toxin
Protein ID: WP_078081377.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
dmul_RS078951828426..1828878+453WP_078081234.1RidA family protein-
dmul_RS079001828888..1829733+846WP_020875556.1PhzF family phenazine biosynthesis protein-
dmul_RS079051829869..1830285-417WP_020875557.1type II toxin-antitoxin system HicB family antitoxin-
dmul_RS197001830295..1830483-189WP_078081235.1type II toxin-antitoxin system HicA family toxin-
dmul_RS079101830630..1831769+1140WP_020875558.1NADH:flavin oxidoreductase-
dmul_RS079151831889..1832131+243WP_020875559.1type II toxin-antitoxin system Phd/YefM family antitoxin-
dmul_RS079201832125..1832391+267WP_040414299.1Txe/YoeB family addiction module toxin-
dmul_RS079251832660..1832974-315WP_020875561.1HigA family addiction module antidote proteinAntitoxin
dmul_RS197051832986..1833267-282WP_078081377.1type II toxin-antitoxin system RelE/ParE family toxinToxin
dmul_RS079301833628..1834113+486WP_020875562.1DUF1772 domain-containing protein-
dmul_RS079351834417..1835040+624WP_040414325.1hydrolase-
dmul_RS079401835195..1835680+486WP_020875564.1group 1 truncated hemoglobin-
dmul_RS079501836356..1837045+690WP_040414326.1aquaporin Z-
dmul_RS079551837098..1838180+1083WP_020875566.1endonuclease/exonuclease/phosphatase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.58 Da        Isoelectric Point: 10.0490

>T62970 WP_078081377.1 NZ_CP015381:c1833267-1832986 [Desulfococcus multivorans]
MIKTFADKETQQLFVSGKSKRLPSDLLRRAIRRLEFIHFANDIKDLLVPRSNRLHALKGDRKGQHSISINDQWRICFRFI
EGDAYDVEVTDYH

Download         Length: 282 bp

>T62970 NZ_CP015381:c1833267-1832986 [Desulfococcus multivorans]
ATGATAAAAACATTTGCCGATAAAGAAACCCAGCAATTATTTGTTTCCGGCAAATCGAAACGCTTACCATCCGATTTATT
ACGAAGGGCAATAAGACGTTTAGAATTTATTCACTTTGCAAATGACATAAAAGACCTTTTGGTGCCACGCAGCAACAGGC
TCCATGCGCTTAAAGGCGACAGGAAAGGGCAACACTCAATATCGATAAATGACCAGTGGCGAATATGTTTCCGTTTCATT
GAAGGCGATGCCTACGATGTTGAGGTTACCGATTACCATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12044.70 Da        Isoelectric Point: 8.6052

>AT62970 WP_020875561.1 NZ_CP015381:c1832974-1832660 [Desulfococcus multivorans]
MAIPNTTKREIKPTHPGEMLREDFMPDYDLNTASMANALGVSRQTINEILRERRAISPAMALRLSRLFSNSPEFWLNAQH
SWDLWDSEKRYSKELSQIRPLNAA

Download         Length: 315 bp

>AT62970 NZ_CP015381:c1832974-1832660 [Desulfococcus multivorans]
ATGGCTATACCCAATACGACAAAGCGTGAAATTAAGCCGACTCATCCCGGTGAAATGCTTAGAGAGGATTTCATGCCGGA
CTATGATCTGAACACGGCTTCCATGGCAAACGCATTAGGCGTGTCACGCCAAACAATTAATGAAATTTTGAGAGAACGAC
GTGCTATCAGTCCGGCTATGGCGCTAAGATTATCTCGACTTTTCAGCAATTCACCGGAATTCTGGCTGAATGCCCAGCAT
TCGTGGGACCTTTGGGATTCGGAAAAACGCTACAGTAAAGAATTGTCTCAAATCCGACCCTTGAATGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References