Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3653291..3654018 Replicon chromosome
Accession NZ_CP015379
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A6V27_RS16505 Protein ID WP_063587072.1
Coordinates 3653291..3653602 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A6V27_RS16510 Protein ID WP_063587073.1
Coordinates 3653599..3654018 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS16470 3649217..3649996 + 780 WP_063587067.1 terminase -
A6V27_RS16475 3650090..3650596 + 507 WP_063587068.1 head completion/stabilization protein -
A6V27_RS16480 3650596..3650799 + 204 WP_063587069.1 tail protein X -
A6V27_RS16485 3650803..3651099 + 297 WP_061553134.1 phage holin family protein -
A6V27_RS16490 3651099..3651599 + 501 WP_063587070.1 glycoside hydrolase family 104 protein -
A6V27_RS16495 3651596..3652021 + 426 WP_063587071.1 Rz-like lysis system protein LysB -
A6V27_RS21180 3652117..3652578 + 462 Protein_3205 phage tail protein -
A6V27_RS16500 3652579..3653028 + 450 WP_063587618.1 phage virion morphogenesis protein -
A6V27_RS16505 3653291..3653602 + 312 WP_063587072.1 type II toxin-antitoxin system HigB family toxin Toxin
A6V27_RS16510 3653599..3654018 + 420 WP_063587073.1 helix-turn-helix domain-containing protein Antitoxin
A6V27_RS16515 3654111..3654848 + 738 WP_145915984.1 hypothetical protein -
A6V27_RS16520 3654979..3655167 + 189 Protein_3210 helix-turn-helix domain-containing protein -
A6V27_RS16525 3655376..3656290 + 915 WP_063587075.1 toll/interleukin-1 receptor domain-containing protein -
A6V27_RS16530 3656460..3656939 - 480 WP_063587619.1 hypothetical protein -
A6V27_RS16535 3657288..3657606 + 319 Protein_3213 hypothetical protein -
A6V27_RS16540 3657808..3658191 + 384 WP_063587076.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3623082..3707611 84529
- flank IS/Tn - - 3654979..3655203 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12437.27 Da        Isoelectric Point: 9.8988

>T62955 WP_063587072.1 NZ_CP015379:3653291-3653602 [Hafnia alvei]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPTEMPTLIPSMDNFKYRNKWWVLNVGGNNLRVIVYINFMNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

>T62955 NZ_CP015379:3653291-3653602 [Hafnia alvei]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCACTGTA
CCGCTTAGTGCGCGAGACGGATTTCTCTTCTCCAACTGAGATGCCAACTCTGATACCGAGCATGGATAATTTCAAGTACC
GGAACAAGTGGTGGGTTTTAAATGTAGGAGGCAACAACTTGAGGGTTATTGTCTATATCAATTTCATGAATAAGCGCTTC
TATGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15361.46 Da        Isoelectric Point: 4.4508

>AT62955 WP_063587073.1 NZ_CP015379:3653599-3654018 [Hafnia alvei]
MITDTAKAIEATKQLIAAVPFLGGSSSESDYREALELVDYLIENDDENPLIDFLVSKIADYEDNSPRFAEFNKANAEMPV
GVALLRTLIDQHKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPELFL

Download         Length: 420 bp

>AT62955 NZ_CP015379:3653599-3654018 [Hafnia alvei]
ATGATTACCGACACCGCAAAAGCCATTGAAGCAACCAAACAACTCATAGCTGCTGTCCCCTTCCTAGGGGGCAGTTCGTC
CGAGAGCGATTACCGCGAAGCGTTGGAGCTGGTGGACTACTTGATCGAGAACGACGACGAGAACCCGCTTATTGACTTTT
TGGTGAGTAAGATTGCCGACTATGAAGATAATAGCCCTCGTTTCGCTGAATTCAACAAAGCTAACGCTGAAATGCCGGTC
GGCGTTGCACTGCTGCGTACCCTGATTGACCAGCACAAGCTGTCTTACTCTGATCTCAAAGAGGAGATCGGCTCTAAATC
ACTGGTTAGCCAGATTCTGTCTGGCCAGCGCTCTTTGACCATTACTCACATTAAGGCACTGTCGGCTCGTTTTGGTGTGA
AACCAGAATTGTTTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References