Detailed information of TA system TA062904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2529042..2529577
• Replicon: chromosome
• Accession: NZ_CP015362
• Organism: Streptomyces sp. S8

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: A6E92_RS10270
• Protein ID: WP_084992497.1
• Coordinates: 2529042..2529296 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1C6MFF4
• Locus tag: A6E92_RS10275
• Protein ID: WP_018491027.1
• Coordinates: 2529293..2529577 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6E92_RS10260	2526873..2527982	-	1110	WP_084992495.1	SPFH/Band 7/PHB domain protein	-
A6E92_RS10265	2528031..2528468	-	438	WP_028416176.1	NfeD family protein	-
A6E92_RS32785	2528669..2529030	-	362	Protein_2025	IS5/IS1182 family transposase	-
A6E92_RS10270	2529042..2529296	-	255	WP_084992497.1	Txe/YoeB family addiction module toxin	Toxin
A6E92_RS10275	2529293..2529577	-	285	WP_018491027.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A6E92_RS10280	2529780..2530868	-	1089	WP_018491026.1	redox-regulated ATPase YchF	-
A6E92_RS10285	2531388..2531960	+	573	WP_084992499.1	hypothetical protein	-
A6E92_RS10290	2532235..2532972	-	738	WP_028416172.1	ROK family protein	-
A6E92_RS10295	2533010..2534041	-	1032	WP_084992500.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10021.56 Da
• Isoelectric Point: 9.7160

>T62904 WP_084992497.1 NZ_CP015362:c2529296-2529042 [Streptomyces sp. S8]
VRLVFEGQGWEDYTSWLKNDRKILARINKLIQDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Nucleotide

• Length: 255 bp

>T62904 NZ_CP015362:c2529296-2529042 [Streptomyces sp. S8]
GTGAGGCTCGTCTTCGAGGGGCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGGAAGATACTCGCTCGGAT
CAACAAGCTCATCCAGGACGTCAAGCGTGACCCCTTCACGGGGATCGGCAAGCCCGAGCCGCTGAAATACCACTTGCCCG
GGGCATGGTCGAGGCGGATCGATGATGAGCACCGCCTCGTCTACCTGGTCACGGACAAGGAAATCGTCATTCTCGCGGCT
CGTTATCACTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10260.53 Da
• Isoelectric Point: 5.1585

>AT62904 WP_018491027.1 NZ_CP015362:c2529577-2529293 [Streptomyces sp. S8]
MSITASEARKELFPLIKKVNENHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALANINVSERDL
IDPDSPDAAREGAA

Nucleotide

• Length: 285 bp

>AT62904 NZ_CP015362:c2529577-2529293 [Streptomyces sp. S8]
ATGTCCATAACTGCGAGTGAAGCCCGCAAGGAACTCTTTCCGCTGATCAAAAAGGTCAACGAGAACCACGAGGCGATCGA
GATCGTCTCCAAGCACGGCAATGCCGTACTTGTCTCGGCCGAGGACTATGCCGCGTTGCGTGAGGGCTCGTACCTGCTGC
GCTCCCCGGCGAATGCCCGTCGCCTGCTCAAGGCGTACGAGAACGCCCTGGCGAACATCAACGTGTCGGAGCGGGATCTG
ATCGACCCCGACTCGCCGGATGCGGCACGTGAGGGTGCCGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C6MFF4