Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1977917..1978574 Replicon chromosome
Accession NZ_CP015283
Organism Streptococcus salivarius strain ATCC 25975

Toxin (Protein)


Gene name higB Uniprot ID A0A1W5ZFU7
Locus tag V471_RS09250 Protein ID WP_045768899.1
Coordinates 1978221..1978574 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1W5ZFV8
Locus tag V471_RS09245 Protein ID WP_045768898.1
Coordinates 1977917..1978219 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V471_RS09235 1973734..1974729 - 996 WP_084871430.1 SIR2 family protein -
V471_RS09240 1974763..1977753 - 2991 WP_084871431.1 type I restriction endonuclease subunit R -
V471_RS09245 1977917..1978219 - 303 WP_045768898.1 helix-turn-helix transcriptional regulator Antitoxin
V471_RS09250 1978221..1978574 - 354 WP_045768899.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
V471_RS09255 1978811..1979575 - 765 WP_045768900.1 SDR family NAD(P)-dependent oxidoreductase -
V471_RS09260 1979607..1980764 - 1158 WP_045768901.1 DUF2974 domain-containing protein -
V471_RS09265 1980874..1981500 + 627 WP_084871432.1 Pr6Pr family membrane protein -
V471_RS09270 1981538..1982379 - 842 Protein_1753 HAD family hydrolase -
V471_RS09275 1982531..1982920 + 390 WP_004182763.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 14100.50 Da        Isoelectric Point: 10.2980

>T62870 WP_045768899.1 NZ_CP015283:c1978574-1978221 [Streptococcus salivarius]
MYPIHFYKDRNGHEPVREYIETLSMNSSKDSRIKLHKIQDYLTMLKNRGTMIGEPFIKHLEGEIWELRPLRDRILFAAWL
DDGFILLHYFVKKTQKTPRRELMKAQKALDDIRKRGL

Download         Length: 354 bp

>T62870 NZ_CP015283:c1978574-1978221 [Streptococcus salivarius]
ATGTATCCTATTCATTTTTATAAAGATAGAAATGGACATGAACCTGTTAGAGAGTATATTGAAACATTATCTATGAATTC
AAGTAAAGATTCTAGAATTAAATTGCATAAAATTCAAGACTACCTGACTATGTTAAAAAATAGAGGAACCATGATTGGTG
AACCATTCATTAAACATTTGGAAGGAGAGATTTGGGAACTAAGACCCTTAAGAGATAGAATTTTATTTGCAGCATGGCTA
GATGATGGTTTTATTTTGCTTCATTATTTTGTGAAAAAGACACAAAAGACTCCAAGACGTGAGCTGATGAAGGCTCAAAA
AGCTTTAGATGATATTAGAAAGCGAGGATTGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10979.96 Da        Isoelectric Point: 10.0576

>AT62870 WP_045768898.1 NZ_CP015283:c1978219-1977917 [Streptococcus salivarius]
MTLEKNPAIGSSWDDLQKTIFTKEEIAASELRVALMLEIIDARKKQGISQKKLEELSGVKQPVIARMEKGKTAPQLDTVL
KILASLGKTLAVVPLDSHVK

Download         Length: 303 bp

>AT62870 NZ_CP015283:c1978219-1977917 [Streptococcus salivarius]
ATGACCCTAGAAAAGAATCCAGCAATTGGAAGTAGTTGGGATGATTTACAGAAAACTATTTTCACTAAAGAGGAAATTGC
GGCGAGTGAACTCCGTGTCGCACTGATGCTTGAGATTATTGATGCTCGTAAAAAACAAGGCATTTCCCAAAAGAAACTAG
AAGAGCTAAGTGGTGTCAAACAACCTGTTATCGCACGTATGGAGAAAGGAAAAACGGCACCTCAGTTAGATACGGTTCTT
AAAATACTGGCTAGTCTAGGAAAGACATTGGCAGTAGTCCCACTTGATTCACATGTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W5ZFU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1W5ZFV8

References