Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1893569..1894081 Replicon chromosome
Accession NZ_CP015282
Organism Streptococcus salivarius strain ATCC 27945

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6A8UFG0
Locus tag NX99_RS08835 Protein ID WP_060971903.1
Coordinates 1893827..1894081 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2I1TMD2
Locus tag NX99_RS08830 Protein ID WP_060971904.1
Coordinates 1893569..1893823 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX99_RS08800 1889363..1889680 + 318 WP_002884193.1 ribosome assembly RNA-binding protein YhbY -
NX99_RS08805 1889788..1890420 + 633 WP_002884372.1 nicotinate-nucleotide adenylyltransferase -
NX99_RS08810 1890417..1891007 + 591 WP_022496426.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
NX99_RS08815 1891031..1891384 + 354 WP_014632696.1 ribosome silencing factor -
NX99_RS08820 1891589..1892329 + 741 WP_022496427.1 class I SAM-dependent methyltransferase -
NX99_RS08825 1892336..1893427 + 1092 WP_084915365.1 nucleotidyltransferase -
NX99_RS08830 1893569..1893823 + 255 WP_060971904.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NX99_RS08835 1893827..1894081 + 255 WP_060971903.1 Txe/YoeB family addiction module toxin Toxin
NX99_RS08840 1894783..1896888 + 2106 WP_002891663.1 ATP-dependent Clp protease ATP-binding subunit -
NX99_RS08845 1897467..1898075 + 609 WP_002884297.1 DUF4230 domain-containing protein -
NX99_RS09995 1898650..1898817 + 168 WP_014634940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10123.60 Da        Isoelectric Point: 8.8499

>T62869 WP_060971903.1 NZ_CP015282:1893827-1894081 [Streptococcus salivarius]
MLLTFTEDAWIDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Download         Length: 255 bp

>T62869 NZ_CP015282:1893827-1894081 [Streptococcus salivarius]
ATGTTACTCACTTTCACTGAAGATGCATGGATAGATTATTGTTATTGGCAAAATCAGGACAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAGCCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGGCGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGTGTCGCCTTTCTCTCTTTT
AAAGATCATTATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9719.00 Da        Isoelectric Point: 4.8782

>AT62869 WP_060971904.1 NZ_CP015282:1893569-1893823 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
ALKE

Download         Length: 255 bp

>AT62869 NZ_CP015282:1893569-1893823 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTGAAGGATTATATGAAAAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAGTGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAGCAT
GCACTAAAGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8UFG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2I1TMD2

References