Detailed information of TA system TA062863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Gp49-HTH_37
• Location: 5271860..5272268
• Replicon: chromosome
• Accession: NZ_CP015281
• Organism: Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: A4R40_RS23130
• Protein ID: WP_109792002.1
• Coordinates: 5272140..5272268 (-)
• Length: 43 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A4R40_RS23125
• Protein ID: WP_011148593.1
• Coordinates: 5271860..5272147 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4R40_RS23105	5267959..5269014	+	1056	WP_011148589.1	hypothetical protein	-
A4R40_RS23110	5269011..5270597	+	1587	WP_011148590.1	AMP-binding protein	-
A4R40_RS23115	5270594..5271217	+	624	WP_011148591.1	CDP-alcohol phosphatidyltransferase family protein	-
A4R40_RS23120	5271207..5271749	+	543	WP_011148592.1	CDP-archaeol synthase	-
A4R40_RS23125	5271860..5272147	-	288	WP_011148593.1	helix-turn-helix domain-containing protein	Antitoxin
A4R40_RS23130	5272140..5272268	-	129	WP_109792002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A4R40_RS23135	5272432..5273577	-	1146	WP_058589582.1	ABC transporter permease	-
A4R40_RS23140	5273577..5274722	-	1146	WP_011148595.1	ABC transporter permease	-
A4R40_RS23145	5274730..5275701	-	972	WP_011148596.1	efflux RND transporter periplasmic adaptor subunit	-
A4R40_RS23150	5275939..5276553	+	615	Protein_4436	ECF transporter S component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-37)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-91)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4960.87 Da
• Isoelectric Point: 9.6013

>T62863 WP_109792002.1 NZ_CP015281:c5272268-5272140 [Photorhabdus laumondii subsp. laumondii]
IHYLFSKGKQVYILRCFVKKTDKTPPSEIELALKRLEDMTYG

Nucleotide

• Length: 129 bp

>T62863 NZ_CP015281:c5272268-5272140 [Photorhabdus laumondii subsp. laumondii]
ATTCATTATCTTTTTTCAAAAGGGAAGCAGGTTTACATTTTACGATGCTTTGTGAAGAAAACAGATAAAACACCACCATC
TGAAATAGAGTTAGCACTGAAACGATTGGAGGATATGACATATGGCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10724.44 Da
• Isoelectric Point: 9.8357

>AT62863 WP_011148593.1 NZ_CP015281:c5272147-5271860 [Photorhabdus laumondii subsp. laumondii]
MAKVTPISHSEVRKRLLNTPEAIQAYVEATEEYELLEQLTEWREKAGLKKIDIAKRMGINPSAVTRIEKNVTKASWHTLK
RYAAACGVELSLTAK

Nucleotide

• Length: 288 bp

>AT62863 NZ_CP015281:c5272147-5271860 [Photorhabdus laumondii subsp. laumondii]
ATGGCTAAAGTAACTCCTATCTCACATTCAGAAGTGAGAAAGCGACTTCTTAATACACCGGAAGCTATACAAGCCTATGT
TGAGGCTACAGAAGAATATGAGCTGCTGGAACAACTCACTGAGTGGCGGGAAAAGGCGGGTCTAAAGAAAATAGATATAG
CTAAACGGATGGGAATTAATCCGTCTGCGGTTACCCGTATTGAGAAGAATGTAACGAAAGCTAGTTGGCACACACTTAAA
CGTTATGCTGCTGCATGTGGTGTTGAGTTATCTTTAACTGCGAAGTAA