62860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4996469..4997819 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name sanaT Uniprot ID Q7MZL3
Locus tag A4R40_RS21895 Protein ID WP_011148367.1
Coordinates 4996469..4997431 (-) Length 321 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID Q7MZL2
Locus tag A4R40_RS21900 Protein ID WP_011148368.1
Coordinates 4997424..4997819 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS21880 4992384..4993349 + 966 WP_011148364.1 ABC transporter substrate-binding protein -
A4R40_RS21885 4993352..4994653 + 1302 WP_011148365.1 SidA/IucD/PvdA family monooxygenase -
A4R40_RS21890 4994678..4996126 + 1449 WP_109791858.1 aminotransferase class V-fold PLP-dependent enzyme -
A4R40_RS21895 4996469..4997431 - 963 WP_011148367.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A4R40_RS21900 4997424..4997819 - 396 WP_011148368.1 hypothetical protein Antitoxin
A4R40_RS21905 4997907..4998482 - 576 WP_041381176.1 DUF3156 family protein -
A4R40_RS21910 4998478..4999971 - 1494 WP_109791859.1 APC family permease -
A4R40_RS21915 5000545..5001204 + 660 WP_011148371.1 helix-turn-helix transcriptional regulator -
A4R40_RS26205 5001450..5001614 - 165 WP_157852095.1 hypothetical protein -
A4R40_RS21920 5001654..5002538 - 885 WP_011144722.1 IS982-like element ISPlu11 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 5001654..5002538 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-305)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 321 a.a.        Molecular weight: 36450.75 Da        Isoelectric Point: 5.7831

>T62860 WP_011148367.1 NZ_CP015281:c4997431-4996469 [Photorhabdus laumondii subsp. laumondii]
MDDLSGLFADVADVLGIGTISIVEKDYYVVELLRLLQPLAFDTHKLVFAGGTALAKAGISLDRMSEDVDIKLVPQPEFLV
GVQYSRSQRKNIRKDIVQTISATIAASGFLGIDDSNPKITRDEYRYNDISVRYPQRVVQVPYLRPFIKLELMESDLLQAA
ERRDIRSFVTQLTGKGRAVEAFPCTTIISTQAEKLVAMLRRTAVFMRNIDRKDDESLVRHLHDNYCIVNAIGVDIRQLAG
FVQQTIEQDIQRYGRQYPQFQISSINELRAGLEELGSNPIYQQRYQQLVIPMVFEHSRIPWAEAYDCFRQTALSVLNELN

Download         Length: 963 bp

>T62860 NZ_CP015281:c4997431-4996469 [Photorhabdus laumondii subsp. laumondii]
ATGGATGATTTATCAGGTTTATTTGCAGATGTTGCCGATGTACTAGGTATCGGTACTATTTCTATTGTGGAAAAAGATTA
CTATGTTGTTGAACTGCTTCGTCTGCTACAGCCTTTAGCGTTTGATACCCATAAACTGGTATTTGCTGGTGGAACAGCGT
TGGCAAAAGCCGGAATTTCACTTGATCGGATGTCGGAAGATGTGGATATCAAACTGGTTCCACAGCCTGAATTTTTGGTG
GGTGTTCAGTACTCCCGATCTCAGCGCAAAAATATCAGAAAGGATATTGTTCAGACGATATCAGCGACTATTGCAGCATC
TGGTTTTTTGGGGATTGACGATAGCAACCCTAAGATCACACGGGATGAATATCGCTACAATGATATTTCGGTCCGCTATC
CCCAACGTGTTGTACAGGTTCCCTACCTCAGGCCATTTATCAAACTGGAGTTGATGGAGTCTGATTTGCTGCAAGCGGCA
GAACGGCGCGATATTCGTTCATTTGTCACGCAACTAACAGGAAAAGGTCGGGCGGTTGAAGCGTTCCCCTGCACGACGAT
TATCAGCACTCAAGCTGAAAAGCTGGTAGCTATGCTGAGACGGACTGCTGTGTTTATGCGTAATATTGATAGAAAGGATG
ACGAGTCACTGGTTCGTCATCTGCATGATAACTACTGCATTGTGAATGCAATAGGAGTGGATATCCGTCAACTTGCTGGT
TTTGTACAACAAACTATTGAACAGGATATTCAGCGCTATGGCCGCCAGTATCCTCAGTTTCAGATTTCGTCGATTAATGA
ACTGAGAGCTGGATTGGAAGAGTTGGGAAGTAATCCCATCTATCAGCAACGTTATCAACAACTTGTGATCCCAATGGTCT
TTGAACATAGTAGAATACCTTGGGCAGAAGCTTACGATTGTTTCCGGCAGACGGCTTTATCTGTTCTGAATGAGCTGAAC
TAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14638.06 Da        Isoelectric Point: 10.8869

>AT62860 WP_011148368.1 NZ_CP015281:c4997819-4997424 [Photorhabdus laumondii subsp. laumondii]
MIIKERIQARLKRSKRYVFIRDDFKDIAGYDQVGRILRGLVKEGQLLKVGYGVYTKARKNSVTGKIMPASPGGSDAVILE
ALERLKVKYHLDGASAAYTDGKSTQIPAYTQIKTTFRFKRVLSVGNSRLNG

Download         Length: 396 bp

>AT62860 NZ_CP015281:c4997819-4997424 [Photorhabdus laumondii subsp. laumondii]
ATGATTATTAAAGAGCGTATTCAGGCGCGTTTGAAGCGATCAAAACGTTATGTGTTCATTCGTGACGACTTTAAAGATAT
TGCTGGTTACGATCAGGTAGGAAGGATACTGCGCGGTTTGGTCAAAGAAGGTCAATTGCTGAAAGTGGGATACGGTGTTT
ACACCAAGGCTCGGAAAAATAGCGTTACTGGGAAAATAATGCCTGCTTCTCCGGGAGGCTCTGATGCGGTTATTCTTGAA
GCGTTAGAGCGTTTAAAGGTGAAATACCATTTGGATGGAGCTTCTGCTGCCTATACTGACGGTAAATCAACACAGATTCC
CGCTTATACCCAAATTAAAACCACATTCCGTTTTAAACGGGTGTTATCGGTGGGGAATAGCCGGTTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JQ95

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JN60

References