21019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4996471..4997821 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name sanaT Uniprot ID Q7MZL3
Locus tag PLU_RS21115 Protein ID WP_011148367.1
Coordinates 4996471..4997433 (-) Length 321 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID Q7MZL2
Locus tag PLU_RS21120 Protein ID WP_011148368.1
Coordinates 4997426..4997821 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS21100 (plu4267) 4992386..4993351 + 966 WP_011148364.1 ABC transporter substrate-binding protein -
PLU_RS21105 (plu4268) 4993354..4994655 + 1302 WP_011148365.1 SidA/IucD/PvdA family monooxygenase -
PLU_RS21110 (plu4269) 4994680..4996128 + 1449 WP_011148366.1 aminotransferase class V-fold PLP-dependent enzyme -
PLU_RS21115 (plu4270) 4996471..4997433 - 963 WP_011148367.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PLU_RS21120 (plu4271) 4997426..4997821 - 396 WP_011148368.1 hypothetical protein Antitoxin
PLU_RS21125 (plu4272) 4997909..4998484 - 576 WP_041381176.1 DUF3156 family protein -
PLU_RS21130 (plu4273) 4998480..4999973 - 1494 WP_011148370.1 APC family permease -
PLU_RS21135 (plu4274) 5000547..5001206 + 660 WP_011148371.1 helix-turn-helix transcriptional regulator -
PLU_RS26975 (plu4275) 5001452..5001616 - 165 WP_157852095.1 hypothetical protein -
PLU_RS21140 (plu4276) 5001656..5002540 - 885 WP_011144722.1 IS982-like element ISPlu11 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 5001656..5002540 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-305)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 321 a.a.        Molecular weight: 36450.75 Da        Isoelectric Point: 5.7831

>T21019 WP_011148367.1 NC_005126:c4997433-4996471 [Photorhabdus laumondii subsp. laumondii TTO1]
MDDLSGLFADVADVLGIGTISIVEKDYYVVELLRLLQPLAFDTHKLVFAGGTALAKAGISLDRMSEDVDIKLVPQPEFLV
GVQYSRSQRKNIRKDIVQTISATIAASGFLGIDDSNPKITRDEYRYNDISVRYPQRVVQVPYLRPFIKLELMESDLLQAA
ERRDIRSFVTQLTGKGRAVEAFPCTTIISTQAEKLVAMLRRTAVFMRNIDRKDDESLVRHLHDNYCIVNAIGVDIRQLAG
FVQQTIEQDIQRYGRQYPQFQISSINELRAGLEELGSNPIYQQRYQQLVIPMVFEHSRIPWAEAYDCFRQTALSVLNELN

Download         Length: 963 bp

>T21019 NC_005126:c4997433-4996471 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGATGATTTATCAGGTTTATTTGCAGATGTTGCCGATGTACTAGGTATCGGTACTATTTCTATTGTGGAAAAAGATTA
CTATGTTGTTGAACTGCTTCGTCTGCTACAGCCTTTAGCGTTTGATACCCATAAACTGGTATTTGCTGGTGGAACAGCGT
TGGCAAAAGCCGGAATTTCACTTGATCGGATGTCGGAAGATGTGGATATCAAACTGGTTCCACAGCCTGAATTTTTGGTG
GGTGTTCAGTACTCCCGATCTCAGCGCAAAAATATCAGAAAGGATATTGTTCAGACGATATCAGCGACTATTGCAGCATC
TGGTTTTTTGGGGATTGACGATAGCAACCCTAAGATCACACGGGATGAATATCGCTACAATGATATTTCGGTCCGCTATC
CCCAACGTGTTGTACAGGTTCCCTACCTCAGGCCATTTATCAAACTGGAGTTGATGGAGTCTGATTTGCTGCAAGCGGCA
GAACGGCGCGATATTCGTTCATTTGTCACGCAACTAACAGGAAAAGGTCGGGCGGTTGAAGCGTTCCCCTGCACGACGAT
TATCAGCACTCAAGCTGAAAAGCTGGTAGCTATGCTGAGACGGACTGCTGTGTTTATGCGTAATATTGATAGAAAGGATG
ACGAGTCACTGGTTCGTCATCTGCATGATAACTACTGCATTGTGAATGCAATAGGAGTGGATATCCGTCAACTTGCTGGT
TTTGTACAACAAACTATTGAACAGGATATTCAGCGCTATGGCCGCCAGTATCCTCAGTTTCAGATTTCGTCGATTAATGA
ACTGAGAGCTGGATTGGAAGAGTTGGGAAGTAATCCCATCTATCAGCAACGTTATCAACAACTTGTGATCCCAATGGTCT
TTGAACATAGTAGAATACCTTGGGCAGAAGCTTACGATTGTTTCCGGCAGACGGCTTTATCTGTTCTGAATGAGCTGAAC
TAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14638.06 Da        Isoelectric Point: 10.8869

>AT21019 WP_011148368.1 NC_005126:c4997821-4997426 [Photorhabdus laumondii subsp. laumondii TTO1]
MIIKERIQARLKRSKRYVFIRDDFKDIAGYDQVGRILRGLVKEGQLLKVGYGVYTKARKNSVTGKIMPASPGGSDAVILE
ALERLKVKYHLDGASAAYTDGKSTQIPAYTQIKTTFRFKRVLSVGNSRLNG

Download         Length: 396 bp

>AT21019 NC_005126:c4997821-4997426 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATTATTAAAGAGCGTATTCAGGCGCGTTTGAAGCGATCAAAACGTTATGTGTTCATTCGTGACGACTTTAAAGATAT
TGCTGGTTACGATCAGGTAGGAAGGATACTGCGCGGTTTGGTCAAAGAAGGTCAATTGCTGAAAGTGGGATACGGTGTTT
ACACCAAGGCTCGGAAAAATAGCGTTACTGGGAAAATAATGCCTGCTTCTCCGGGAGGCTCTGATGCGGTTATTCTTGAA
GCGTTAGAGCGTTTAAAGGTGAAATACCATTTGGATGGAGCTTCTGCTGCCTATACTGACGGTAAATCAACACAGATTCC
CGCTTATACCCAAATTAAAACCACATTCCGTTTTAAACGGGTGTTATCGGTGGGGAATAGCCGGTTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JQ95

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JN60

References