Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2707234..2707811 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name PumA Uniprot ID Q7N4L8
Locus tag A4R40_RS11940 Protein ID WP_011146555.1
Coordinates 2707509..2707811 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A4R40_RS11935 Protein ID WP_011146554.1
Coordinates 2707234..2707512 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS11895 2702951..2703502 - 552 WP_109791569.1 type VI secretion system contractile sheath small subunit -
A4R40_RS11900 2704227..2704481 + 255 WP_011146550.1 hypothetical protein -
A4R40_RS11905 2704726..2705601 - 876 WP_011146551.1 phage tail protein -
A4R40_RS11915 2706246..2706518 + 273 WP_011146552.1 CopG family ribbon-helix-helix protein -
A4R40_RS11920 2706506..2706796 + 291 WP_011146553.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4R40_RS11930 2707021..2707197 + 177 Protein_2271 IS1595 family transposase -
A4R40_RS11935 2707234..2707512 - 279 WP_011146554.1 putative addiction module antidote protein Antitoxin
A4R40_RS11940 2707509..2707811 - 303 WP_011146555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS11945 2707909..2708049 + 141 WP_082302859.1 recombinase family protein -
A4R40_RS11950 2708042..2708230 - 189 Protein_2275 helix-turn-helix domain-containing protein -
A4R40_RS11955 2708220..2708309 - 90 Protein_2276 class A beta-lactamase -
A4R40_RS11960 2709004..2710857 + 1854 WP_011146556.1 hypothetical protein -
A4R40_RS11965 2710875..2711900 - 1026 WP_011146066.1 IS630-like element ISPlu3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 2706958..2711900 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-87)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11303.07 Da        Isoelectric Point: 9.8100

>T62847 WP_011146555.1 NZ_CP015281:c2707811-2707509 [Photorhabdus laumondii subsp. laumondii]
MITVLSTETFDNWIDALKDIRVKTKIQARIRRLKNGNSGDIEPVGEGFSEMRIHEGKGYRVYLKNHGKVIVVLLCGGDKS
TQQKDIARAKAIYKEIEGEL

Download         Length: 303 bp

>T62847 NZ_CP015281:c2707811-2707509 [Photorhabdus laumondii subsp. laumondii]
ATGATAACTGTATTAAGTACAGAAACATTTGATAACTGGATTGATGCCCTGAAAGACATCAGGGTAAAAACAAAGATTCA
GGCACGAATTCGCAGACTGAAAAACGGTAATTCTGGCGATATAGAGCCAGTAGGGGAAGGGTTTTCAGAAATGCGGATTC
ATGAAGGTAAAGGCTACAGGGTTTATCTAAAAAATCACGGAAAAGTAATCGTTGTTTTGTTGTGTGGGGGAGATAAAAGT
ACACAGCAAAAAGATATAGCCAGAGCAAAAGCCATTTACAAAGAGATTGAGGGGGAGCTATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10203.76 Da        Isoelectric Point: 5.6105

>AT62847 WP_011146554.1 NZ_CP015281:c2707512-2707234 [Photorhabdus laumondii subsp. laumondii]
MKLKEYDIAEHLNSEEEMQMYLNEIMEDGDPALVLSALGDIARARNMSQLSREVGMSREGLYHALSGKGNPTFSAMMKIT
KALGLKLHFTGA

Download         Length: 279 bp

>AT62847 NZ_CP015281:c2707512-2707234 [Photorhabdus laumondii subsp. laumondii]
ATGAAACTGAAAGAATATGATATTGCAGAACACTTAAACAGTGAAGAAGAAATGCAAATGTATCTTAATGAAATTATGGA
AGATGGTGATCCGGCATTGGTACTGTCTGCGCTGGGTGATATTGCCAGAGCCAGAAACATGAGCCAGCTTTCAAGAGAGG
TCGGTATGTCCAGAGAAGGGCTATATCATGCTCTTTCAGGAAAAGGTAATCCAACATTCAGCGCTATGATGAAAATAACA
AAAGCGTTAGGGCTGAAACTTCATTTCACAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JRW2

Antitoxin

Source ID Structure

References