21006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2707235..2707812 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name PumA Uniprot ID Q7N4L8
Locus tag PLU_RS11520 Protein ID WP_011146555.1
Coordinates 2707510..2707812 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PLU_RS11515 Protein ID WP_011146554.1
Coordinates 2707235..2707513 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS11485 (plu2301) 2702952..2703503 - 552 WP_011146549.1 type VI secretion system contractile sheath small subunit -
PLU_RS11490 (plu2302) 2704228..2704482 + 255 WP_011146550.1 hypothetical protein -
PLU_RS11495 (plu2303) 2704727..2705602 - 876 WP_011146551.1 phage tail protein -
PLU_RS11500 (plu2305) 2706247..2706519 + 273 WP_011146552.1 CopG family ribbon-helix-helix protein -
PLU_RS11505 (plu2306) 2706507..2706797 + 291 WP_011146553.1 type II toxin-antitoxin system RelE/ParE family toxin -
PLU_RS26035 2707022..2707198 + 177 Protein_2279 IS1595 family transposase -
PLU_RS11515 (plu2308) 2707235..2707513 - 279 WP_011146554.1 putative addiction module antidote protein Antitoxin
PLU_RS11520 (plu2309) 2707510..2707812 - 303 WP_011146555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLU_RS25340 (plu2311) 2707910..2708050 + 141 WP_082302859.1 recombinase family protein -
PLU_RS27160 2708043..2708231 - 189 Protein_2283 helix-turn-helix domain-containing protein -
PLU_RS26690 (plu2312) 2708221..2708310 - 90 Protein_2284 class A beta-lactamase -
PLU_RS11525 (plu2313) 2709005..2710858 + 1854 WP_011146556.1 hypothetical protein -
PLU_RS11530 (plu2314) 2710876..2711901 - 1026 WP_011146066.1 IS630-like element ISPlu3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 2706959..2711901 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-87)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11303.07 Da        Isoelectric Point: 9.8100

>T21006 WP_011146555.1 NC_005126:c2707812-2707510 [Photorhabdus laumondii subsp. laumondii TTO1]
MITVLSTETFDNWIDALKDIRVKTKIQARIRRLKNGNSGDIEPVGEGFSEMRIHEGKGYRVYLKNHGKVIVVLLCGGDKS
TQQKDIARAKAIYKEIEGEL

Download         Length: 303 bp

>T21006 NC_005126:c2707812-2707510 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATAACTGTATTAAGTACAGAAACATTTGATAACTGGATTGATGCCCTGAAAGACATCAGGGTAAAAACAAAGATTCA
GGCACGAATTCGCAGACTGAAAAACGGTAATTCTGGCGATATAGAGCCAGTAGGGGAAGGGTTTTCAGAAATGCGGATTC
ATGAAGGTAAAGGCTACAGGGTTTATCTAAAAAATCACGGAAAAGTAATCGTTGTTTTGTTGTGTGGGGGAGATAAAAGT
ACACAGCAAAAAGATATAGCCAGAGCAAAAGCCATTTACAAAGAGATTGAGGGGGAGCTATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10203.76 Da        Isoelectric Point: 5.6105

>AT21006 WP_011146554.1 NC_005126:c2707513-2707235 [Photorhabdus laumondii subsp. laumondii TTO1]
MKLKEYDIAEHLNSEEEMQMYLNEIMEDGDPALVLSALGDIARARNMSQLSREVGMSREGLYHALSGKGNPTFSAMMKIT
KALGLKLHFTGA

Download         Length: 279 bp

>AT21006 NC_005126:c2707513-2707235 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGAAACTGAAAGAATATGATATTGCAGAACACTTAAACAGTGAAGAAGAAATGCAAATGTATCTTAATGAAATTATGGA
AGATGGTGATCCGGCATTGGTACTGTCTGCGCTGGGTGATATTGCCAGAGCCAGAAACATGAGCCAGCTTTCAAGAGAGG
TCGGTATGTCCAGAGAAGGGCTATATCATGCTCTTTCAGGAAAAGGTAATCCAACATTCAGCGCTATGATGAAAATAACA
AAAGCGTTAGGGCTGAAACTTCATTTCACAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JRW2

Antitoxin

Source ID Structure

References