Detailed information of TA system TA062841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 2485286..2485936
• Replicon: chromosome
• Accession: NZ_CP015281
• Organism: Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q7N558
• Locus tag: A4R40_RS10875
• Protein ID: WP_011146354.1
• Coordinates: 2485601..2485936 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A4R40_RS10870
• Protein ID: WP_011146353.1
• Coordinates: 2485286..2485600 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4R40_RS10845	2480556..2481293	-	738	WP_058588603.1	cyclase family protein	-
A4R40_RS10850	2481897..2482451	+	555	WP_011146349.1	cytochrome b	-
A4R40_RS10855	2482478..2483056	+	579	WP_109791519.1	YceI family protein	-
A4R40_RS10860	2483370..2483738	-	369	WP_011146351.1	hypothetical protein	-
A4R40_RS10865	2484707..2485270	+	564	WP_109791520.1	VOC family protein	-
A4R40_RS10870	2485286..2485600	-	315	WP_011146353.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
A4R40_RS10875	2485601..2485936	-	336	WP_011146354.1	hypothetical protein	Toxin
A4R40_RS10880	2485991..2486149	+	159	Protein_2062	VOC family protein	-
A4R40_RS10885	2486287..2487033	+	747	WP_011146355.1	copper homeostasis protein CutC	-
A4R40_RS10890	2487209..2488180	-	972	WP_011146356.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
A4R40_RS10895	2488177..2488935	-	759	WP_011146357.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
A4R40_RS10900	2489208..2489459	+	252	WP_011146358.1	plasmid stabilization protein	-
A4R40_RS10905	2489449..2489739	+	291	WP_011146359.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A4R40_RS10910	2489866..2490261	-	396	WP_011146360.1	MAPEG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (13-98)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13393.51 Da
• Isoelectric Point: 10.1960

>T62841 WP_011146354.1 NZ_CP015281:c2485936-2485601 [Photorhabdus laumondii subsp. laumondii]
MEAVFIELPPFERYRHNYLSDEEFRTFQNMLLKNPTTGDVIQHTGGLRKVRFTDSRRKKGKRGGIRIIYYWWVSKSQFML
FTIYDKDEMSDLTKEQCESLRKMLEMRKKGA

Nucleotide

• Length: 336 bp

>T62841 NZ_CP015281:c2485936-2485601 [Photorhabdus laumondii subsp. laumondii]
ATGGAAGCTGTTTTTATTGAACTACCACCTTTTGAACGTTACCGTCATAACTACCTGAGTGATGAGGAGTTTCGAACCTT
CCAAAATATGCTGCTGAAAAATCCAACAACAGGAGATGTAATCCAACATACAGGCGGATTGCGTAAAGTACGTTTTACTG
ATTCCCGAAGGAAAAAGGGAAAACGAGGCGGTATTCGGATAATTTACTATTGGTGGGTATCTAAATCGCAATTCATGCTT
TTCACTATCTATGATAAAGATGAAATGTCAGACTTAACTAAAGAGCAATGCGAATCCTTGCGTAAAATGTTAGAAATGAG
AAAAAAAGGAGCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12059.89 Da
• Isoelectric Point: 10.1310

>AT62841 WP_011146353.1 NZ_CP015281:c2485600-2485286 [Photorhabdus laumondii subsp. laumondii]
MKRDLFAELNEGMKAWEEANEGKLTLKTHKRRLKNDIFISPDELKSIRSKLNISQAVFAQYLHTGETTYQNWEQGRAKPN
KQAVLLIKMVERNPQALEFLASLT

Nucleotide

• Length: 315 bp

>AT62841 NZ_CP015281:c2485600-2485286 [Photorhabdus laumondii subsp. laumondii]
ATGAAGCGTGATCTATTTGCAGAACTCAATGAAGGGATGAAAGCTTGGGAAGAGGCTAACGAAGGCAAACTCACATTGAA
AACTCATAAGAGGAGGTTAAAAAATGATATCTTCATCAGTCCGGATGAGTTGAAATCTATCCGGAGTAAACTGAATATTT
CTCAGGCTGTTTTTGCCCAGTACCTGCATACCGGTGAGACGACATACCAAAACTGGGAACAGGGACGGGCTAAACCGAAT
AAACAAGCTGTGTTACTGATTAAAATGGTGGAGCGCAACCCGCAGGCACTAGAATTTCTTGCCAGCCTCACATAA

Structures

Toxin

• AlphaFold DB: A0A6L9JGM0