Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 993019..993589 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4R40_RS04465 Protein ID WP_109791351.1
Coordinates 993308..993589 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4R40_RS04460 Protein ID WP_011145233.1
Coordinates 993019..993297 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS04430 989172..989435 + 264 WP_058588659.1 helix-turn-helix domain-containing protein -
A4R40_RS04435 989805..990350 + 546 WP_011145228.1 hypoxanthine phosphoribosyltransferase -
A4R40_RS04440 990571..990849 + 279 WP_011145229.1 DUF1778 domain-containing protein -
A4R40_RS04445 990854..991354 + 501 WP_011145230.1 GNAT family N-acetyltransferase -
A4R40_RS04450 991509..992048 + 540 WP_041379935.1 SocA family protein -
A4R40_RS04455 992383..992919 + 537 WP_109791350.1 hypoxanthine phosphoribosyltransferase -
A4R40_RS04460 993019..993297 - 279 WP_011145233.1 HigA family addiction module antidote protein Antitoxin
A4R40_RS04465 993308..993589 - 282 WP_109791351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS04475 995109..995762 - 654 WP_011145235.1 carbonate dehydratase -
A4R40_RS04480 995950..996861 + 912 WP_011145236.1 ABC transporter ATP-binding protein -
A4R40_RS04485 996873..997643 + 771 WP_011145237.1 ABC transporter permease -
A4R40_RS04490 997722..998102 - 381 WP_011145238.1 aspartate 1-decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10603.26 Da        Isoelectric Point: 10.4815

>T62837 WP_109791351.1 NZ_CP015281:c993589-993308 [Photorhabdus laumondii subsp. laumondii]
MIKSFKHKGLEKFFKTGSTAGIQPKHALKLQIQLTALNTAKKPEDMNAPSWKLHPLKGANLSGHWAISVNGNWRLTFRFE
GEDIILVNYQDYH

Download         Length: 282 bp

>T62837 NZ_CP015281:c993589-993308 [Photorhabdus laumondii subsp. laumondii]
ATGATTAAAAGCTTCAAACACAAAGGATTGGAAAAATTTTTCAAAACTGGTTCTACCGCTGGCATTCAGCCTAAGCATGC
CCTAAAGCTGCAAATCCAGCTAACTGCATTGAATACGGCTAAAAAACCAGAAGATATGAATGCCCCTAGCTGGAAACTTC
ACCCACTAAAAGGAGCAAATCTTAGCGGTCACTGGGCAATATCTGTTAACGGTAATTGGCGTTTAACATTTAGATTTGAG
GGCGAAGATATAATTCTCGTTAATTATCAAGATTATCACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9992.63 Da        Isoelectric Point: 9.7351

>AT62837 WP_011145233.1 NZ_CP015281:c993297-993019 [Photorhabdus laumondii subsp. laumondii]
MKMHKPAHPGIVLREYLGDISVTEAAKALGITRAALSRILNGNAGISADMALRLEAALGTSAEMWTGMQSQYELWIASQH
KRPEIKPILAHS

Download         Length: 279 bp

>AT62837 NZ_CP015281:c993297-993019 [Photorhabdus laumondii subsp. laumondii]
ATGAAAATGCATAAACCTGCACACCCAGGCATAGTTTTGCGTGAATATCTTGGTGACATATCTGTCACGGAAGCAGCAAA
GGCTCTCGGTATAACCAGAGCTGCACTATCCCGCATATTAAACGGCAATGCAGGAATATCTGCTGATATGGCCCTGCGAC
TGGAAGCCGCATTAGGTACTAGTGCCGAAATGTGGACAGGAATGCAGTCCCAATATGAACTGTGGATTGCCTCACAGCAC
AAAAGACCAGAAATAAAACCAATACTGGCTCACTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References