Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 277163..277704 Replicon chromosome
Accession NZ_CP015244
Organism Escherichia coli O91 str. RM7190

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag I51_RS01310 Protein ID WP_000615982.1
Coordinates 277163..277441 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag I51_RS01315 Protein ID WP_000729704.1
Coordinates 277444..277704 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I51_RS01295 274745..275323 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
I51_RS01300 275529..276296 + 768 WP_000333380.1 class II glutamine amidotransferase -
I51_RS01305 276267..277007 - 741 WP_001225679.1 murein L,D-transpeptidase -
I51_RS01310 277163..277441 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
I51_RS01315 277444..277704 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
I51_RS01320 277890..278663 + 774 WP_000543899.1 C40 family peptidase -
I51_RS01325 278720..279076 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
I51_RS01330 279069..279347 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
I51_RS01335 279452..281164 - 1713 Protein_246 flagellar biosynthesis protein FlhA -
I51_RS01340 281136..281921 + 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T62761 WP_000615982.1 NZ_CP015244:c277441-277163 [Escherichia coli O91 str. RM7190]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T62761 NZ_CP015244:c277441-277163 [Escherichia coli O91 str. RM7190]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT62761 WP_000729704.1 NZ_CP015244:c277704-277444 [Escherichia coli O91 str. RM7190]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT62761 NZ_CP015244:c277704-277444 [Escherichia coli O91 str. RM7190]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References