62741

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 2897493..2897905 Replicon chromosome
Accession NZ_CP015241
Organism Escherichia coli strain 2013C-4465

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag A5955_RS14260 Protein ID WP_000132630.1
Coordinates 2897493..2897834 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 2897829..2897905 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5955_RS14240 2893503..2894915 - 1413 WP_000199330.1 PLP-dependent aminotransferase family protein -
A5955_RS14245 2895092..2895256 + 165 WP_000394274.1 DUF1127 domain-containing protein -
A5955_RS30260 2895353..2896235 + 883 Protein_2689 DUF262 domain-containing protein -
A5955_RS30265 2896283..2897446 + 1164 Protein_2690 DUF1524 domain-containing protein -
A5955_RS14260 2897493..2897834 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 2897829..2897905 + 77 NuclAT_37 - Antitoxin
- 2897829..2897905 + 77 NuclAT_37 - Antitoxin
- 2897829..2897905 + 77 NuclAT_37 - Antitoxin
- 2897829..2897905 + 77 NuclAT_37 - Antitoxin
- 2897829..2897905 + 77 NuclAT_38 - Antitoxin
- 2897829..2897905 + 77 NuclAT_38 - Antitoxin
- 2897829..2897905 + 77 NuclAT_38 - Antitoxin
- 2897829..2897905 + 77 NuclAT_38 - Antitoxin
A5955_RS14265 2898055..2899809 - 1755 WP_000110083.1 restriction endonuclease subunit S -
A5955_RS14270 2899809..2901278 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2887001..2905706 18705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T62741 WP_000132630.1 NZ_CP015241:c2897834-2897493 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T62741 NZ_CP015241:c2897834-2897493 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT62741 NZ_CP015241:2897829-2897905 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References