Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2191950..2192552 Replicon chromosome
Accession NZ_CP015240
Organism Escherichia coli strain 2011C-3911

Toxin (Protein)


Gene name higB Uniprot ID A0A8T6BLC1
Locus tag A5956_RS11445 Protein ID WP_000897306.1
Coordinates 2191950..2192261 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A5956_RS11450 Protein ID WP_000356397.1
Coordinates 2192262..2192552 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5956_RS11415 2186980..2187765 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
A5956_RS11420 2187864..2188463 + 600 WP_001295269.1 glucose-1-phosphatase -
A5956_RS11425 2188457..2189329 + 873 WP_000920762.1 virulence factor BrkB family protein -
A5956_RS11430 2189326..2189763 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
A5956_RS11435 2189808..2190749 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
A5956_RS11440 2190813..2191721 - 909 WP_001162704.1 alpha/beta hydrolase -
A5956_RS11445 2191950..2192261 + 312 WP_000897306.1 hypothetical protein Toxin
A5956_RS11450 2192262..2192552 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
A5956_RS11460 2193138..2193356 + 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
A5956_RS11465 2193575..2193817 + 243 WP_001087409.1 hypothetical protein -
A5956_RS11475 2194147..2195076 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
A5956_RS11480 2195073..2195708 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
A5956_RS11485 2195705..2196607 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12319.35 Da        Isoelectric Point: 9.7791

>T62716 WP_000897306.1 NZ_CP015240:2191950-2192261 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKWKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T62716 NZ_CP015240:2191950-2192261 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGTGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT62716 WP_000356397.1 NZ_CP015240:2192262-2192552 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT62716 NZ_CP015240:2192262-2192552 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References