Detailed information of TA system TA062702

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 51403..51657
• Replicon: plasmid unnamed1
• Accession: NZ_CP015239
• Organism: Escherichia coli strain 2011C-3911

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: A5956_RS00210
• Protein ID: WP_032211975.1
• Coordinates: 51403..51609 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	51601..51657 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5956_RS00180	47061..47810	-	750	Protein_35	ISKra4-like element ISEc51 family transposase	-
A5956_RS24790	47810..48148	+	339	Protein_36	Tn3 family transposase	-
A5956_RS24795	48487..48726	-	240	WP_071978018.1	MarR family transcriptional regulator	-
A5956_RS26460	48739..48999	-	261	WP_072148071.1	hypothetical protein	-
A5956_RS00195	49702..50559	-	858	WP_064055973.1	incFII family plasmid replication initiator RepA	-
A5956_RS00200	50552..50626	-	75	WP_001365571.1	RepA leader peptide Tap	-
A5956_RS00205	50862..51119	-	258	WP_000084404.1	replication regulatory protein RepA	-
A5956_RS00210	51403..51609	-	207	WP_032211975.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	51601..51657	+	57	NuclAT_1	-	Antitoxin
-	51601..51657	+	57	NuclAT_1	-	Antitoxin
-	51601..51657	+	57	NuclAT_1	-	Antitoxin
-	51601..51657	+	57	NuclAT_1	-	Antitoxin
A5956_RS00215	51832..52215	-	384	WP_028985877.1	hypothetical protein	-
A5956_RS00220	52318..52779	-	462	WP_000760076.1	thermonuclease family protein	-
A5956_RS00230	53880..54437	-	558	WP_028985878.1	fertility inhibition protein FinO	-
A5956_RS00235	54473..54841	-	369	WP_000722534.1	NirD/YgiW/YdeI family stress tolerance protein	-
A5956_RS00240	54924..55670	-	747	WP_028985879.1	type-F conjugative transfer system pilin acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..125977	125977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7836.33 Da
• Isoelectric Point: 9.2439

>T62702 WP_032211975.1 NZ_CP015239:c51609-51403 [Escherichia coli]
MKYLNTTDCSLFLAERSKFMTKYALIGLLAVCATVLFFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 207 bp

>T62702 NZ_CP015239:c51609-51403 [Escherichia coli]
ATGAAGTACTTGAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTTTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT62702 NZ_CP015239:51601-51657 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin