Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1979679..1980328 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name higB Uniprot ID A0A2W0G579
Locus tag A4308_RS09440 Protein ID WP_045281668.1
Coordinates 1979966..1980328 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag A4308_RS09435 Protein ID WP_014882863.1
Coordinates 1979679..1979978 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS09425 1976104..1978077 + 1974 WP_045281669.1 PhoX family phosphatase -
A4308_RS09430 1978180..1979568 + 1389 WP_023332293.1 phenylalanine transporter -
A4308_RS09435 1979679..1979978 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
A4308_RS09440 1979966..1980328 - 363 WP_045281668.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4308_RS09445 1980534..1981769 + 1236 WP_023332295.1 MFS transporter -
A4308_RS09450 1981785..1982810 + 1026 WP_045281667.1 sugar phosphate isomerase/epimerase -
A4308_RS09455 1982803..1983945 + 1143 WP_063308501.1 Gfo/Idh/MocA family oxidoreductase -
A4308_RS09460 1984021..1984992 + 972 WP_045281665.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13910.87 Da        Isoelectric Point: 5.6482

>T62637 WP_045281668.1 NZ_CP015227:c1980328-1979966 [Enterobacter sp. ODB01]
MWNVETTDIFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T62637 NZ_CP015227:c1980328-1979966 [Enterobacter sp. ODB01]
ATGTGGAATGTCGAGACAACGGACATATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAGC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT62637 WP_014882863.1 NZ_CP015227:c1979978-1979679 [Enterobacter sp. ODB01]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT62637 NZ_CP015227:c1979978-1979679 [Enterobacter sp. ODB01]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
AAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCCACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G579

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References