Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1582678..1583324 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4308_RS07570 Protein ID WP_032637796.1
Coordinates 1582974..1583324 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4308_RS07565 Protein ID WP_032635284.1
Coordinates 1582678..1582977 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS07535 1578091..1579050 - 960 WP_023336511.1 DUF523 and DUF1722 domain-containing protein -
A4308_RS07540 1579154..1579564 - 411 WP_014881954.1 hydroxyisourate hydrolase -
A4308_RS07545 1579664..1580389 - 726 WP_045269330.1 MerR family transcriptional regulator -
A4308_RS07550 1580507..1581031 + 525 WP_045281336.1 lipocalin family protein -
A4308_RS07555 1581110..1582108 + 999 WP_045281334.1 class I SAM-dependent methyltransferase -
A4308_RS07560 1582211..1582648 + 438 WP_045281332.1 acetyltransferase -
A4308_RS07565 1582678..1582977 - 300 WP_032635284.1 XRE family transcriptional regulator Antitoxin
A4308_RS07570 1582974..1583324 - 351 WP_032637796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4308_RS07575 1583854..1584195 - 342 WP_032635286.1 SymE family type I addiction module toxin -
A4308_RS21715 1584326..1584529 + 204 WP_071890797.1 toxin-antitoxin system HicB family antitoxin -
A4308_RS07580 1584526..1585090 - 565 Protein_1452 hypothetical protein -
A4308_RS07590 1585552..1586943 + 1392 WP_045281331.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13483.49 Da        Isoelectric Point: 6.9811

>T62635 WP_032637796.1 NZ_CP015227:c1583324-1582974 [Enterobacter sp. ODB01]
MWTVLFGKVFELWLLEQEEGLQEKVLADMLNLQNYGPRLPRPYADTVKGSQYNNMKELRVQYAGRPIRALFAFDPERQAI
VLCAGNKSNDKAFYEKLIRIADDEFTRHLTSLETAK

Download         Length: 351 bp

>T62635 NZ_CP015227:c1583324-1582974 [Enterobacter sp. ODB01]
ATGTGGACGGTACTGTTCGGAAAGGTGTTTGAGCTATGGTTGCTTGAACAGGAAGAAGGGTTACAGGAAAAGGTACTGGC
AGACATGCTAAATCTACAAAACTATGGACCTCGTCTTCCTCGTCCCTATGCCGATACTGTAAAAGGCTCGCAATATAACA
ATATGAAAGAGTTACGTGTTCAATACGCTGGTCGTCCGATTCGTGCTTTATTCGCATTTGACCCCGAACGTCAGGCGATT
GTGCTTTGCGCAGGCAACAAGAGTAACGACAAGGCATTTTATGAAAAACTCATTCGCATTGCAGATGATGAATTTACCCG
GCATCTGACAAGCCTGGAGACAGCCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11160.04 Da        Isoelectric Point: 6.9842

>AT62635 WP_032635284.1 NZ_CP015227:c1582977-1582678 [Enterobacter sp. ODB01]
VKTLNELIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT62635 NZ_CP015227:c1582977-1582678 [Enterobacter sp. ODB01]
GTGAAAACACTAAATGAATTAATTGCATCACGCTCACCGGAAAGCCAACAACGAATTAAAGAAATGGCAGAGGAAATGAT
CCTTGAAACGGGTTTGCAACTTTTACGTGAAGAGCTCAGGCTTTCGCAAAAAAATGTTGCCGAGCTAATGGGGGTGAGCC
AGCCCGCAGTAACACAAATAGAGCAACGTGGAAATGAACTAAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGT
GGGAAACTTTGTATCGACGTTGAACTTCCAACAGGAAAACGCGTTGCGTTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References