Detailed information of TA system TA062591

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2699630..2699937
• Replicon: chromosome
• Accession: NZ_CP015173
• Organism: Staphylococcus aureus strain RIVM6519

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A5J11_RS14665
• Protein ID: WP_011447039.1
• Coordinates: 2699761..2699937 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2699630..2699769 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5J11_RS13515	2695196..2695375	+	180	WP_000669791.1	hypothetical protein	-
A5J11_RS13525	2695686..2695946	+	261	WP_001791826.1	hypothetical protein	-
A5J11_RS13530	2695999..2696349	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
A5J11_RS13535	2696860..2697195	-	336	Protein_2581	SH3 domain-containing protein	-
A5J11_RS13540	2697846..2698337	-	492	WP_000920038.1	staphylokinase	-
A5J11_RS13545	2698528..2699283	-	756	WP_000861038.1	CHAP domain-containing protein	-
A5J11_RS13550	2699295..2699549	-	255	WP_000611512.1	phage holin	-
A5J11_RS13555	2699601..2699708	+	108	WP_031762631.1	hypothetical protein	-
-	2699630..2699769	+	140	NuclAT_0	-	Antitoxin
-	2699630..2699769	+	140	NuclAT_0	-	Antitoxin
-	2699630..2699769	+	140	NuclAT_0	-	Antitoxin
-	2699630..2699769	+	140	NuclAT_0	-	Antitoxin
A5J11_RS14665	2699761..2699937	-	177	WP_011447039.1	putative holin-like toxin	Toxin
A5J11_RS13560	2700140..2700913	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
A5J11_RS13565	2701334..2701708	-	375	WP_000340977.1	hypothetical protein	-
A5J11_RS13570	2701764..2702051	-	288	WP_001040255.1	hypothetical protein	-
A5J11_RS13575	2702098..2702250	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see / hlb / groEL	2695999..2746773	50774

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T62591 WP_011447039.1 NZ_CP015173:c2699937-2699761 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T62591 NZ_CP015173:c2699937-2699761 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT62591 NZ_CP015173:2699630-2699769 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin