Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 371670..371854 Replicon chromosome
Accession NZ_CP015173
Organism Staphylococcus aureus strain RIVM6519

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag A5J11_RS01985 Protein ID WP_000482652.1
Coordinates 371747..371854 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 371670..371730 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5J11_RS01960 367125..367292 - 168 Protein_371 hypothetical protein -
A5J11_RS01970 367523..369256 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
A5J11_RS01975 369281..371044 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 371670..371730 + 61 - - Antitoxin
A5J11_RS01985 371747..371854 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
A5J11_RS01990 371988..372374 - 387 WP_000779360.1 flippase GtxA -
A5J11_RS01995 372642..373784 + 1143 WP_001176863.1 glycerate kinase -
A5J11_RS02000 373844..374503 + 660 WP_000831298.1 membrane protein -
A5J11_RS02005 374685..375896 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
A5J11_RS02010 376019..376492 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T62584 WP_000482652.1 NZ_CP015173:c371854-371747 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T62584 NZ_CP015173:c371854-371747 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT62584 NZ_CP015173:371670-371730 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References