Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 14974..15515 Replicon plasmid unnamed3
Accession NZ_CP015171
Organism Acetobacter ascendens strain LMG 1591

Toxin (Protein)


Gene name yoeB Uniprot ID G2I8S5
Locus tag A4R89_RS15725 Protein ID WP_014106724.1
Coordinates 14974..15243 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G2I8S6
Locus tag A4R89_RS15730 Protein ID WP_010668421.1
Coordinates 15240..15515 (-) Length 92 a.a.

Genomic Context

A4R89_RS15715A4R89_RS15755A4R89_RS15760A4R89_RS15710A4R89_RS15720A4R89_RS15725A4R89_RS15730A4R89_RS15735A4R89_RS15740A4R89_RS15745A4R89_RS15750
Location: 11819..14164 (2346 bp)
Type: Others
Protein ID: Protein_8
Location: 19725..20084 (360 bp)
Type: Others
Protein ID: WP_211274218.1
Location: 20149..20388 (240 bp)
Type: Others
Protein ID: WP_070325633.1
Location: 10338..11723 (1386 bp)
Type: Others
Protein ID: WP_070325023.1
Location: 14290..14961 (672 bp)
Type: Others
Protein ID: WP_173572193.1
Location: 14974..15243 (270 bp)
Type: Toxin
Protein ID: WP_014106724.1
Location: 15240..15515 (276 bp)
Type: Antitoxin
Protein ID: WP_010668421.1
Location: 15741..15878 (138 bp)
Type: Others
Protein ID: WP_070325623.1
Location: 15904..16296 (393 bp)
Type: Others
Protein ID: WP_010668423.1
Location: 16293..16487 (195 bp)
Type: Others
Protein ID: WP_010516209.1
Location: 16542..19628 (3087 bp)
Type: Others
Protein ID: WP_070325624.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A4R89_RS1571010338..11723-1386WP_070325023.1IS1380-like element IS1380A family transposase-
A4R89_RS1571511819..14164+2346Protein_8restriction endonuclease subunit R-
A4R89_RS1572014290..14961-672WP_173572193.1hypothetical protein-
A4R89_RS1572514974..15243-270WP_014106724.1Txe/YoeB family addiction module toxinToxin
A4R89_RS1573015240..15515-276WP_010668421.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
A4R89_RS1573515741..15878-138WP_070325623.1plasmid stabilization protein-
A4R89_RS1574015904..16296-393WP_010668423.1PIN domain nuclease-
A4R89_RS1574516293..16487-195WP_010516209.1type II toxin-antitoxin system VapB family antitoxin-
A4R89_RS1575016542..19628-3087WP_070325624.1Ti-type conjugative transfer relaxase TraA-
A4R89_RS1575519725..20084+360WP_211274218.1conjugal transfer protein TraD-
A4R89_RS1576020149..20388+240WP_070325633.1conjugal transfer protein TraD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmid--1..2818628186
-flankIS/Tn--10338..117231385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10563.91 Da        Isoelectric Point: 7.3582

>T62578 WP_014106724.1 NZ_CP015171:c15243-14974 [Acetobacter ascendens]
VKVIFHEDGWEDYLSWFQSDNAVLEKINALIEDVRRHPFQGIGKPEPLKGQLSGWWSRRITGEHRLVYRVQGRAGEDQRI
EIAQCRFHY

Download         Length: 270 bp

>T62578 NZ_CP015171:c15243-14974 [Acetobacter ascendens]
GTGAAAGTCATTTTTCATGAAGATGGCTGGGAGGATTATCTTTCGTGGTTTCAGTCAGACAATGCGGTTCTTGAGAAGAT
CAATGCCCTGATCGAGGATGTGCGTCGGCATCCGTTTCAGGGGATAGGGAAGCCGGAACCCCTGAAGGGGCAGCTTTCTG
GGTGGTGGTCCCGACGGATTACGGGAGAACATCGTCTGGTCTACCGGGTTCAGGGGCGCGCGGGAGAGGATCAGCGGATC
GAGATTGCCCAGTGCCGGTTTCATTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10206.37 Da        Isoelectric Point: 5.1070

>AT62578 WP_010668421.1 NZ_CP015171:c15515-15240 [Acetobacter ascendens]
MTYVSYTDLRQNLAHYLDEAVNSRAPIVVTRKTGKGSVVLMSEEEFSGWQETVHLLSSPRNAERLLRSIRDIEHGAATEH
DLLEPQGEPSA

Download         Length: 276 bp

>AT62578 NZ_CP015171:c15515-15240 [Acetobacter ascendens]
ATGACCTATGTTTCCTATACCGACCTGCGCCAGAACCTGGCGCATTATCTGGACGAAGCAGTGAACAGCCGTGCGCCGAT
TGTCGTGACCCGCAAGACCGGGAAAGGCAGTGTCGTGCTGATGTCGGAAGAAGAATTCTCCGGCTGGCAGGAAACCGTGC
ATCTCCTGAGCAGCCCACGCAACGCGGAGAGGCTGTTGCGGAGCATTCGTGACATCGAGCACGGGGCGGCAACCGAGCAT
GATCTTCTGGAGCCTCAGGGTGAACCGTCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A149R123

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A149R124

References