Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3176362..3176894 Replicon chromosome
Accession NZ_CP015163
Organism Amycolatopsis albispora strain WP1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4R43_RS14785 Protein ID WP_113692866.1
Coordinates 3176691..3176894 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4R43_RS14780 Protein ID WP_113692865.1
Coordinates 3176362..3176694 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R43_RS14755 3171700..3172677 - 978 WP_113692861.1 ABC transporter permease -
A4R43_RS14760 3172674..3174224 - 1551 WP_113697602.1 sugar ABC transporter ATP-binding protein -
A4R43_RS14765 3174277..3174855 - 579 WP_113692862.1 hypothetical protein -
A4R43_RS14770 3175040..3175624 + 585 WP_113692863.1 DNA-binding protein -
A4R43_RS14775 3175675..3176331 + 657 WP_113692864.1 RES family NAD+ phosphorylase -
A4R43_RS14780 3176362..3176694 - 333 WP_113692865.1 XRE family transcriptional regulator Antitoxin
A4R43_RS14785 3176691..3176894 - 204 WP_113692866.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R43_RS14790 3176934..3177443 - 510 WP_113692867.1 GNAT family N-acetyltransferase -
A4R43_RS14795 3177440..3179371 - 1932 WP_113692868.1 S9 family peptidase -
A4R43_RS14800 3179412..3180467 - 1056 WP_113692869.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-56)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7318.18 Da        Isoelectric Point: 9.1264

>T62567 WP_113692866.1 NZ_CP015163:c3176894-3176691 [Amycolatopsis albispora]
VRGGSAQCGSGGSTEVRILFAFDPRRRAILLVGGDKAGDWRGWYTANIPVAERRYDQHLRGLEEAGT

Download         Length: 204 bp

>T62567 NZ_CP015163:c3176894-3176691 [Amycolatopsis albispora]
GTGCGAGGTGGATCCGCTCAGTGCGGATCTGGTGGAAGCACGGAGGTTCGGATCCTGTTCGCGTTCGACCCGCGCCGCCG
GGCGATCCTGCTGGTGGGCGGGGACAAGGCGGGTGACTGGCGTGGGTGGTACACCGCGAACATCCCGGTGGCCGAACGGC
GGTATGACCAACATCTGCGCGGGCTGGAGGAGGCGGGGACATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12229.75 Da        Isoelectric Point: 9.8780

>AT62567 WP_113692865.1 NZ_CP015163:c3176694-3176362 [Amycolatopsis albispora]
MSRSWREVKAEKEERDRAAGRDVEEARASARETTDAYLVGFRLAQLRQQAGVSQAELARRIGISQPRVSQLENGDLAQME
LDTIRRYIAALGGRLRVVAGFGDRDVVVSA

Download         Length: 333 bp

>AT62567 NZ_CP015163:c3176694-3176362 [Amycolatopsis albispora]
ATGAGCCGATCTTGGCGGGAAGTCAAGGCTGAGAAGGAAGAGCGAGATCGCGCCGCCGGGCGGGATGTCGAGGAAGCGCG
GGCATCCGCACGGGAGACCACCGACGCCTACCTCGTCGGCTTCCGGCTGGCACAGCTTCGGCAGCAAGCCGGGGTGAGCC
AGGCCGAACTCGCCCGGCGGATCGGGATCAGCCAGCCGCGGGTGAGCCAGTTGGAGAACGGCGACCTCGCCCAGATGGAG
CTGGACACGATCCGCCGCTACATCGCCGCGCTCGGTGGGCGGTTGCGCGTGGTGGCCGGGTTCGGCGACCGCGACGTCGT
GGTGAGCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References