Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 382396..383714 Replicon chromosome
Accession NZ_CP015159
Organism Escherichia coli strain Eco889

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag WM90_RS01950 Protein ID WP_001262467.1
Coordinates 382396..383403 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag WM90_RS01955 Protein ID WP_001312177.1
Coordinates 383403..383714 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM90_RS01915 377606..377797 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
WM90_RS01920 377794..379473 + 1680 Protein_365 cellulose biosynthesis protein BcsG -
WM90_RS28975 379559..379666 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
WM90_RS29675 380042..380149 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
- 380206..380263 + 58 NuclAT_26 - -
- 380206..380263 + 58 NuclAT_26 - -
- 380206..380263 + 58 NuclAT_26 - -
- 380206..380263 + 58 NuclAT_26 - -
WM90_RS28985 380525..380632 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 380681..380746 + 66 NuclAT_27 - -
- 380681..380746 + 66 NuclAT_27 - -
- 380681..380746 + 66 NuclAT_27 - -
- 380681..380746 + 66 NuclAT_27 - -
WM90_RS01945 381108..382379 + 1272 WP_001545666.1 amino acid permease -
WM90_RS01950 382396..383403 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
WM90_RS01955 383403..383714 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
WM90_RS01960 383699..384022 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
WM90_RS01965 384247..385260 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
WM90_RS01970 385257..386240 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
WM90_RS01975 386251..387153 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
WM90_RS01980 387163..388182 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T62520 WP_001262467.1 NZ_CP015159:c383403-382396 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T62520 NZ_CP015159:c383403-382396 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTATGGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAGCTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT62520 WP_001312177.1 NZ_CP015159:c383714-383403 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT62520 NZ_CP015159:c383714-383403 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTATGCCCCGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGATGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References